Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells
Visceral obesity is a relevant pathological condition closely associated with high risk of atherosclerotic vascular disease including myocardial infarction and stroke. The increased vascular risk is related also to peculiar dysfunction in the endocrine activity of adipose tissue responsible of vasc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/174341 |
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| _version_ | 1832549602258059264 |
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| author | Giovanni Anfossi Isabella Russo Gabriella Doronzo Alice Pomero Mariella Trovati |
| author_facet | Giovanni Anfossi Isabella Russo Gabriella Doronzo Alice Pomero Mariella Trovati |
| author_sort | Giovanni Anfossi |
| collection | DOAJ |
| description | Visceral obesity is a relevant pathological condition closely associated with high risk of atherosclerotic vascular disease including myocardial infarction and stroke. The increased vascular risk is related also to peculiar dysfunction in the endocrine activity of adipose tissue responsible of vascular impairment (including endothelial dysfunction), prothrombotic tendency, and low-grade chronic inflammation. In particular, increased synthesis and release of different cytokines, including interleukins and tumor necrosis factor-α (TNF-α), and adipokines—such as leptin—have been reported as associated with future cardiovascular events. Since vascular cell dysfunction plays a major role in the atherothrombotic complications in central obesity, this paper aims at focusing, in particular, on the relationship between platelets and vascular smooth muscle cells, and the impaired secretory pattern of adipose tissue. |
| format | Article |
| id | doaj-art-a5273b8fd786424ca8263ba6cb1b603f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a5273b8fd786424ca8263ba6cb1b603f2025-02-03T06:10:57ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/174341174341Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle CellsGiovanni Anfossi0Isabella Russo1Gabriella Doronzo2Alice Pomero3Mariella Trovati4Department of Clinical and Biological Sciences, Internal Medicine and Metabolic Disease Unit, San Luigi Gonzaga Hospital, San Luigi Gonzaga Faculty of Medicine of the Turin University, Orbassano,10043 Turin, ItalyDepartment of Clinical and Biological Sciences, Internal Medicine and Metabolic Disease Unit, San Luigi Gonzaga Hospital, San Luigi Gonzaga Faculty of Medicine of the Turin University, Orbassano,10043 Turin, ItalyDepartment of Clinical and Biological Sciences, Internal Medicine and Metabolic Disease Unit, San Luigi Gonzaga Hospital, San Luigi Gonzaga Faculty of Medicine of the Turin University, Orbassano,10043 Turin, ItalyDepartment of Clinical and Biological Sciences, Internal Medicine and Metabolic Disease Unit, San Luigi Gonzaga Hospital, San Luigi Gonzaga Faculty of Medicine of the Turin University, Orbassano,10043 Turin, ItalyDepartment of Clinical and Biological Sciences, Internal Medicine and Metabolic Disease Unit, San Luigi Gonzaga Hospital, San Luigi Gonzaga Faculty of Medicine of the Turin University, Orbassano,10043 Turin, ItalyVisceral obesity is a relevant pathological condition closely associated with high risk of atherosclerotic vascular disease including myocardial infarction and stroke. The increased vascular risk is related also to peculiar dysfunction in the endocrine activity of adipose tissue responsible of vascular impairment (including endothelial dysfunction), prothrombotic tendency, and low-grade chronic inflammation. In particular, increased synthesis and release of different cytokines, including interleukins and tumor necrosis factor-α (TNF-α), and adipokines—such as leptin—have been reported as associated with future cardiovascular events. Since vascular cell dysfunction plays a major role in the atherothrombotic complications in central obesity, this paper aims at focusing, in particular, on the relationship between platelets and vascular smooth muscle cells, and the impaired secretory pattern of adipose tissue.http://dx.doi.org/10.1155/2010/174341 |
| spellingShingle | Giovanni Anfossi Isabella Russo Gabriella Doronzo Alice Pomero Mariella Trovati Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells Mediators of Inflammation |
| title | Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells |
| title_full | Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells |
| title_fullStr | Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells |
| title_full_unstemmed | Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells |
| title_short | Adipocytokines in Atherothrombosis: Focus on Platelets and Vascular Smooth Muscle Cells |
| title_sort | adipocytokines in atherothrombosis focus on platelets and vascular smooth muscle cells |
| url | http://dx.doi.org/10.1155/2010/174341 |
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