RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol‐Triggered MET Activation

RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol‐Triggered MET Activation

Abstract Metastasis remains a significant challenge in the treatment of hepatocellular carcinoma (HCC). The role of ribonuclease T2 (RNASET2) in HCC is still uncertain, although it has been reported to have contradictory effects on some cancers. Here, it is demonstrated that RNASET2 knockout leads t...

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Main Authors: Yanquan Xu, Yu Chen, Jiangang Zhang, Jingchun Wang, Shuai Yang, Huakan Zhao, Lei Wu, Juan Lei, Yu Zhou, Jin Peng, Lu Jiang, Qian Chen, Rong Xin, Jianyun Zhou, Yongsheng Li
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
cholesterol
hepatocellular carcinoma
metastasis
MET
ribonuclease
Online Access:https://doi.org/10.1002/advs.202411888
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