Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada
Allograft failure secondary to recurrence of hepatitis C virus (HCV) infection is the most common cause of death and retransplantation among recipients with HCV infection. It has been suggested that patients transplanted for HCV have had worse outcomes in more recent years than in previous years (th...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2008/127684 |
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| _version_ | 1850160678075105280 |
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| author | Kymberly DS Watt Kelly W Burak Marc Deschênes Les Lilly Denis Marleau Paul Marotta Andrew Mason Kevork M Peltekian Eberhard Renner Eric M Yoshida for the Canadian Transplant Hepatology Outcomes Research Network |
| author_facet | Kymberly DS Watt Kelly W Burak Marc Deschênes Les Lilly Denis Marleau Paul Marotta Andrew Mason Kevork M Peltekian Eberhard Renner Eric M Yoshida for the Canadian Transplant Hepatology Outcomes Research Network |
| author_sort | Kymberly DS Watt |
| collection | DOAJ |
| description | Allograft failure secondary to recurrence of hepatitis C virus (HCV) infection is the most common cause of death and retransplantation among recipients with HCV infection. It has been suggested that patients transplanted for HCV have had worse outcomes in more recent years than in previous years (the ‘era effect’). A Canadian transplantation registry database was analyzed to determine the outcomes of patients transplanted over the years for HCV. The results of the present analysis of 1002 patients show that the ‘era effect’ was not seen in liver transplantation recipients with HCV in Canada, because no survival difference was noted based on the year of transplantation. All groups had overall two-year and five-year survival rates of 76% to 83% and 69% to 72%, respectively. The present study’s national results prove continued benefit to transplantation of HCV patients. |
| format | Article |
| id | doaj-art-a51b5dde45ae4df28acc02fd2696c92a |
| institution | OA Journals |
| issn | 0835-7900 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-a51b5dde45ae4df28acc02fd2696c92a2025-08-20T02:23:06ZengWileyCanadian Journal of Gastroenterology0835-79002008-01-0122215315410.1155/2008/127684Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in CanadaKymberly DS Watt0Kelly W Burak1Marc Deschênes2Les Lilly3Denis Marleau4Paul Marotta5Andrew Mason6Kevork M Peltekian7Eberhard Renner8Eric M Yoshida9for the Canadian Transplant Hepatology Outcomes Research NetworkDivision of Gastroenterology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, CanadaUniversity of Calgary Liver Unit, Calgary, Alberta, CanadaMcGill University Health Centre, Montreal, Quebec, CanadaUniversity of Toronto, University Health Network Liver Transplant Program, Toronto, Ontario, CanadaSt. Luc Hospital, Centre Hospitalier de l’Université de Montreal, University of Montreal, Montreal, Quebec, CanadaDivision of Gastroenterology, Department of Medicine, University of Western Ontario, Liver Unit, London Health Sciences Centre, London, Ontario, CanadaDivision of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, CanadaSection of Hepatology, Department of Internal Medicine, University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, CanadaDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaAllograft failure secondary to recurrence of hepatitis C virus (HCV) infection is the most common cause of death and retransplantation among recipients with HCV infection. It has been suggested that patients transplanted for HCV have had worse outcomes in more recent years than in previous years (the ‘era effect’). A Canadian transplantation registry database was analyzed to determine the outcomes of patients transplanted over the years for HCV. The results of the present analysis of 1002 patients show that the ‘era effect’ was not seen in liver transplantation recipients with HCV in Canada, because no survival difference was noted based on the year of transplantation. All groups had overall two-year and five-year survival rates of 76% to 83% and 69% to 72%, respectively. The present study’s national results prove continued benefit to transplantation of HCV patients.http://dx.doi.org/10.1155/2008/127684 |
| spellingShingle | Kymberly DS Watt Kelly W Burak Marc Deschênes Les Lilly Denis Marleau Paul Marotta Andrew Mason Kevork M Peltekian Eberhard Renner Eric M Yoshida for the Canadian Transplant Hepatology Outcomes Research Network Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada Canadian Journal of Gastroenterology |
| title | Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada |
| title_full | Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada |
| title_fullStr | Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada |
| title_full_unstemmed | Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada |
| title_short | Survival after Liver Transplantation for Hepatitis C Is Unchanged over Two Decades in Canada |
| title_sort | survival after liver transplantation for hepatitis c is unchanged over two decades in canada |
| url | http://dx.doi.org/10.1155/2008/127684 |
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