Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain

Targeting and cytotoxicity of chimeric antigen receptor T cells grafted with PD1 extramembrane domain

Abstract Background Immunosuppression induced by programmed cell death protein 1 (PD1) presents a significant constraint on the effectiveness of chimeric antigen receptor (CAR)-T therapy. The potential of combining PD1/PDL1 (Programmed cell death 1 ligand 1) axis blockade with CAR-T cell therapy is...

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Main Authors: Ang Zhang, Shenyu Wang, Yao Sun, Yikun Zhang, Long Zhao, Yang Yang, Yijian Zhang, Lei Xu, Yangyang Lei, Jie Du, Hu Chen, Lian Duan, Mingyi He, Lintao Shi, Lei Liu, Quanjun Wang, Liangding Hu, Bin Zhang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Experimental Hematology & Oncology
Subjects:
Chimeric antigen receptor T cell
PD1
Off-target toxicity
Hinge domain
Tumor microenvironment
Online Access:https://doi.org/10.1186/s40164-023-00438-7
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