Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy
Tissue repair is an extremely crucial part of clinical treatment. During the course of disease treatment, surgery, chemotherapy, and radiotherapy cause tissue damage. On the other hand, Normal tissue from accidental or therapeutic exposure to high-dose radiation can cause severe tissue damage. There...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-01-01
|
| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/09636897241311019 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850083038411620352 |
|---|---|
| author | Ning Wang Feifei Ma Huijuan Song Ningning He Huanteng Zhang Jianguo Li Qiang Liu Chang Xu |
| author_facet | Ning Wang Feifei Ma Huijuan Song Ningning He Huanteng Zhang Jianguo Li Qiang Liu Chang Xu |
| author_sort | Ning Wang |
| collection | DOAJ |
| description | Tissue repair is an extremely crucial part of clinical treatment. During the course of disease treatment, surgery, chemotherapy, and radiotherapy cause tissue damage. On the other hand, Normal tissue from accidental or therapeutic exposure to high-dose radiation can cause severe tissue damage. There is an urgent need for developing medical countermeasures against radiation injury for tissue repair. Tissue repair involves the regeneration, proliferation, differentiation, and migration of tissue cells; imbalance of local tissue homeostasis, progressive chronic inflammation; decreased cell activity and stem cell function; and wound healing. Although many clinical treatments are currently available for tissue repair, they are expensive. The long recovery time and some unavoidable complications such as cell damage and the inflammatory reaction caused by radiotherapy have led to unsatisfactory results. Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have similar tissue repair functions as MSCs. In tissue damage, EVs can be used as an alternative to stem cell therapy, thereby avoiding related complications such as immunological rejection. EVs play a major role in regulating tissue damage, anti-inflammation, pro-proliferation, and immune response, thus providing a diversified and efficient solution for the repair of disease- and radiotherapy-induced tissue damage. This article reviews the research progress of mesenchymal stem cell-derived EVs in promoting the repair of tissue including heart, lung, liver, intestine, skin, blood system, central nervous system, and tissue damage caused by radiotherapy, thereby aiming to offer new directions and ideas for the radiotherapy and regenerative applications. |
| format | Article |
| id | doaj-art-a5178f4dcdb44614bf53bcc0e4897dde |
| institution | DOAJ |
| issn | 1555-3892 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj-art-a5178f4dcdb44614bf53bcc0e4897dde2025-08-20T02:44:22ZengSAGE PublishingCell Transplantation1555-38922025-01-013410.1177/09636897241311019Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and RadiotherapyNing Wang0Feifei Ma1Huijuan Song2Ningning He3Huanteng Zhang4Jianguo Li5Qiang Liu6Chang Xu7School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, ChinaSchool of Basic Medicine Sciences, Shandong Second Medical University, Weifang, ChinaTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, State Key Laboratory of Advanced Medical Materials and Devices, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, ChinaTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, State Key Laboratory of Advanced Medical Materials and Devices, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, ChinaTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, State Key Laboratory of Advanced Medical Materials and Devices, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, ChinaSchool of Basic Medicine Sciences, Shandong Second Medical University, Weifang, ChinaTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, State Key Laboratory of Advanced Medical Materials and Devices, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, ChinaTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, State Key Laboratory of Advanced Medical Materials and Devices, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, ChinaTissue repair is an extremely crucial part of clinical treatment. During the course of disease treatment, surgery, chemotherapy, and radiotherapy cause tissue damage. On the other hand, Normal tissue from accidental or therapeutic exposure to high-dose radiation can cause severe tissue damage. There is an urgent need for developing medical countermeasures against radiation injury for tissue repair. Tissue repair involves the regeneration, proliferation, differentiation, and migration of tissue cells; imbalance of local tissue homeostasis, progressive chronic inflammation; decreased cell activity and stem cell function; and wound healing. Although many clinical treatments are currently available for tissue repair, they are expensive. The long recovery time and some unavoidable complications such as cell damage and the inflammatory reaction caused by radiotherapy have led to unsatisfactory results. Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have similar tissue repair functions as MSCs. In tissue damage, EVs can be used as an alternative to stem cell therapy, thereby avoiding related complications such as immunological rejection. EVs play a major role in regulating tissue damage, anti-inflammation, pro-proliferation, and immune response, thus providing a diversified and efficient solution for the repair of disease- and radiotherapy-induced tissue damage. This article reviews the research progress of mesenchymal stem cell-derived EVs in promoting the repair of tissue including heart, lung, liver, intestine, skin, blood system, central nervous system, and tissue damage caused by radiotherapy, thereby aiming to offer new directions and ideas for the radiotherapy and regenerative applications.https://doi.org/10.1177/09636897241311019 |
| spellingShingle | Ning Wang Feifei Ma Huijuan Song Ningning He Huanteng Zhang Jianguo Li Qiang Liu Chang Xu Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy Cell Transplantation |
| title | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy |
| title_full | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy |
| title_fullStr | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy |
| title_short | Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy |
| title_sort | mesenchymal stem cell derived extracellular vesicles for regenerative applications and radiotherapy |
| url | https://doi.org/10.1177/09636897241311019 |
| work_keys_str_mv | AT ningwang mesenchymalstemcellderivedextracellularvesiclesforregenerativeapplicationsandradiotherapy AT feifeima mesenchymalstemcellderivedextracellularvesiclesforregenerativeapplicationsandradiotherapy AT huijuansong mesenchymalstemcellderivedextracellularvesiclesforregenerativeapplicationsandradiotherapy AT ningninghe mesenchymalstemcellderivedextracellularvesiclesforregenerativeapplicationsandradiotherapy AT huantengzhang mesenchymalstemcellderivedextracellularvesiclesforregenerativeapplicationsandradiotherapy AT jianguoli mesenchymalstemcellderivedextracellularvesiclesforregenerativeapplicationsandradiotherapy AT qiangliu mesenchymalstemcellderivedextracellularvesiclesforregenerativeapplicationsandradiotherapy AT changxu mesenchymalstemcellderivedextracellularvesiclesforregenerativeapplicationsandradiotherapy |