Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi Dogs
Abstract Background Synbiotic products are those Functional foods/feeds that contain both probiotic and prebiotic strains and have health-promoting effects beyond probiotics or prebiotics alone. This study aimed to investigate the effect of synbiotic feed containing the probiotic strain Lactobacillu...
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BMC
2025-05-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-025-04763-3 |
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| author | Ali Khatami Hadi Pourjafar Mehrdad Neshat Gharamaleki |
| author_facet | Ali Khatami Hadi Pourjafar Mehrdad Neshat Gharamaleki |
| author_sort | Ali Khatami |
| collection | DOAJ |
| description | Abstract Background Synbiotic products are those Functional foods/feeds that contain both probiotic and prebiotic strains and have health-promoting effects beyond probiotics or prebiotics alone. This study aimed to investigate the effect of synbiotic feed containing the probiotic strain Lactobacillus acidophilus La5 (1012 cfu/g) and inulin (5%) on changes in Thyroid hormones (T3, T4), TSH, LH, FSH, and Testosterone in male dogs throughout 24 days. Materials and methods In addition to the basic feed, the dogs in the treatment group also received the synbiotic supplement at 5% in each of their three meals during 24 days. Then, the serum levels of LH, FSH, TSH, and Testosterone were measured with an ELISA kit and finally, the obtained data were statistically analyzed. Results The results showed that the consumption of this formulated synbiotic feed had no negative effect on the profile of Thyroid hormones (T3: from 1.09 ± 0.51 to 0.95 ± 0.40 ng/ml [p > 0.05]; and T4: from 6.60 ± 4.33 to 4.70 ± 4.29 µg/dl [p > 0.05]) as well as TSH (from 0.07 ± 0.09 to 0.03 ± 0.00 mIU/L [p > 0.05]), Testosterone (from 1.56 ± 0.66 to 1.26 ± 0.93 ng/ml [p > 0.05]), FSH (from 4.72 ± 1.12 to 11.55 ± 3.42 mIU/ml [p = 0.008]), LH (from 0.56 ± 0.48 to 0.31 ± 0.15 mIU/ml [p > 0.05]), and the changes in the amounts of these hormones was in the normal range during 24 days. Conclusion It concluded that the consumption of synbiotic feed (L. acidophilus + inulin, at the rate of 5%) in male dogs has no significant adverse effects were observed within the study period on Thyroid, TSH, and sex hormones and it seems that it may be used for a long time to take health-promoting effects without harming hormonal activities. |
| format | Article |
| id | doaj-art-a4ff2bd9d88044c6bd4daa7c2399b089 |
| institution | DOAJ |
| issn | 1746-6148 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | BMC Veterinary Research |
| spelling | doaj-art-a4ff2bd9d88044c6bd4daa7c2399b0892025-08-20T02:55:29ZengBMCBMC Veterinary Research1746-61482025-05-012111810.1186/s12917-025-04763-3Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi DogsAli Khatami0Hadi Pourjafar1Mehrdad Neshat Gharamaleki2Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad UniversityDietary Supplements and Probiotic Research Center, Alborz University of Medical SciencesDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad UniversityAbstract Background Synbiotic products are those Functional foods/feeds that contain both probiotic and prebiotic strains and have health-promoting effects beyond probiotics or prebiotics alone. This study aimed to investigate the effect of synbiotic feed containing the probiotic strain Lactobacillus acidophilus La5 (1012 cfu/g) and inulin (5%) on changes in Thyroid hormones (T3, T4), TSH, LH, FSH, and Testosterone in male dogs throughout 24 days. Materials and methods In addition to the basic feed, the dogs in the treatment group also received the synbiotic supplement at 5% in each of their three meals during 24 days. Then, the serum levels of LH, FSH, TSH, and Testosterone were measured with an ELISA kit and finally, the obtained data were statistically analyzed. Results The results showed that the consumption of this formulated synbiotic feed had no negative effect on the profile of Thyroid hormones (T3: from 1.09 ± 0.51 to 0.95 ± 0.40 ng/ml [p > 0.05]; and T4: from 6.60 ± 4.33 to 4.70 ± 4.29 µg/dl [p > 0.05]) as well as TSH (from 0.07 ± 0.09 to 0.03 ± 0.00 mIU/L [p > 0.05]), Testosterone (from 1.56 ± 0.66 to 1.26 ± 0.93 ng/ml [p > 0.05]), FSH (from 4.72 ± 1.12 to 11.55 ± 3.42 mIU/ml [p = 0.008]), LH (from 0.56 ± 0.48 to 0.31 ± 0.15 mIU/ml [p > 0.05]), and the changes in the amounts of these hormones was in the normal range during 24 days. Conclusion It concluded that the consumption of synbiotic feed (L. acidophilus + inulin, at the rate of 5%) in male dogs has no significant adverse effects were observed within the study period on Thyroid, TSH, and sex hormones and it seems that it may be used for a long time to take health-promoting effects without harming hormonal activities.https://doi.org/10.1186/s12917-025-04763-3SynbioticProbioticPrebioticThyroid hormonesTSHSex hormones |
| spellingShingle | Ali Khatami Hadi Pourjafar Mehrdad Neshat Gharamaleki Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi Dogs BMC Veterinary Research Synbiotic Probiotic Prebiotic Thyroid hormones TSH Sex hormones |
| title | Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi Dogs |
| title_full | Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi Dogs |
| title_fullStr | Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi Dogs |
| title_full_unstemmed | Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi Dogs |
| title_short | Short-term effects of a synbiotic diet on thyroid and sex hormones in Sarabi Dogs |
| title_sort | short term effects of a synbiotic diet on thyroid and sex hormones in sarabi dogs |
| topic | Synbiotic Probiotic Prebiotic Thyroid hormones TSH Sex hormones |
| url | https://doi.org/10.1186/s12917-025-04763-3 |
| work_keys_str_mv | AT alikhatami shorttermeffectsofasynbioticdietonthyroidandsexhormonesinsarabidogs AT hadipourjafar shorttermeffectsofasynbioticdietonthyroidandsexhormonesinsarabidogs AT mehrdadneshatgharamaleki shorttermeffectsofasynbioticdietonthyroidandsexhormonesinsarabidogs |