Arecoline, a main alkaloid in Areca catechu, induces biological changes in human papillomavirus 16-positive cervical cancer cells via upregulation of viral oncogenes and cellular transcriptional factors

Arecoline, a main alkaloid in Areca catechu, induces biological changes in human papillomavirus 16-positive cervical cancer cells via upregulation of viral oncogenes and cellular transcriptional factors

Objective: To investigate the effects of arecoline on HPV-positive cervical cells and unveil its underlying mechanism in cervical carcinogenesis. Methods: The cytotoxicity of arecoline was determined and the effect of subtoxic concentrations of arecoline on the expression of viral oncoproteins and t...

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Bibliographic Details
Main Authors: Jureeporn Chuerduangphui, Chaleampol Loymunkong, Tipaya Ekalaksananan, Chamsai Pientong
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-03-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
arecoline
human papillomavirus
oncogenes
cervical cancer
c-fos
Online Access:https://journals.lww.com/10.4103/apjtb.apjtb_693_24
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