STAT3/TGFBI signaling promotes the temozolomide resistance of glioblastoma through upregulating glycolysis by inducing cellular senescence

STAT3/TGFBI signaling promotes the temozolomide resistance of glioblastoma through upregulating glycolysis by inducing cellular senescence

Abstract Glioblastoma (GBM) is the most lethal type of brain tumor. Recent studies have indicated that cellular senescence-targeted therapy is a promising approach for cancer treatment. However, the underlying mechanisms remain to be clarified. In this study, 101 unique combinations of 10 machine le...

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Bibliographic Details
Main Authors: Yanbin Zhang, Xiaohua Xiao, Ge Yang, Xiaobing Jiang, Shujie Jiao, Yingli Nie, Tao Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cancer Cell International
Subjects:
Glioblastoma
Senescence
Glycolysis
Machine learning
Prognosis
Online Access:https://doi.org/10.1186/s12935-025-03770-6
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