APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY
The clinical significance of the SLCO1B1 gene polymorphism (encoding an organic anion transport polipeptide) in the development of statin induced myopathy is considered. Possible tactics of statin dose determination on the basis of pharmacogenetic testing is discussed. Indications for the use of thi...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/299 |
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| _version_ | 1849227956434501632 |
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| author | D. A. Sychev G. N. Shuev A. B. Prokofiev |
| author_facet | D. A. Sychev G. N. Shuev A. B. Prokofiev |
| author_sort | D. A. Sychev |
| collection | DOAJ |
| description | The clinical significance of the SLCO1B1 gene polymorphism (encoding an organic anion transport polipeptide) in the development of statin induced myopathy is considered. Possible tactics of statin dose determination on the basis of pharmacogenetic testing is discussed. Indications for the use of this approach in clinical practice that should increase the efficacy and safety of the statin therapy are also considered. |
| format | Article |
| id | doaj-art-a4f83e5b9de34c619e92d60317c2f719 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-a4f83e5b9de34c619e92d60317c2f7192025-08-23T10:00:18ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-019669870010.20996/1819-6446-2013-9-6-698-700299APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPYD. A. Sychev0G. N. Shuev1A. B. Prokofiev2Russian Medical Academy of Postgraduate Education, Center for Clinical Pharmacology, Research Center for Evaluation of Medical Products, MoscowI.M. Sechenov First Moscow State Medical University, MoscowCenter for Clinical Pharmacology, Research Center for Evaluation of Medical Products, MoscowThe clinical significance of the SLCO1B1 gene polymorphism (encoding an organic anion transport polipeptide) in the development of statin induced myopathy is considered. Possible tactics of statin dose determination on the basis of pharmacogenetic testing is discussed. Indications for the use of this approach in clinical practice that should increase the efficacy and safety of the statin therapy are also considered.https://www.rpcardio.online/jour/article/view/299pharmacogeneticsstatinsmyopathyslco1b1personalized medicine |
| spellingShingle | D. A. Sychev G. N. Shuev A. B. Prokofiev APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY Рациональная фармакотерапия в кардиологии pharmacogenetics statins myopathy slco1b1 personalized medicine |
| title | APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY |
| title_full | APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY |
| title_fullStr | APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY |
| title_full_unstemmed | APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY |
| title_short | APPLIED ASPECTS OF SLCO1B1 PHARMACOGENETIC TESTING FOR PREDICTING OF STATIN-INDUCED MYOPATHY AND PERSONALIZATION OF STATINS THERAPY |
| title_sort | applied aspects of slco1b1 pharmacogenetic testing for predicting of statin induced myopathy and personalization of statins therapy |
| topic | pharmacogenetics statins myopathy slco1b1 personalized medicine |
| url | https://www.rpcardio.online/jour/article/view/299 |
| work_keys_str_mv | AT dasychev appliedaspectsofslco1b1pharmacogenetictestingforpredictingofstatininducedmyopathyandpersonalizationofstatinstherapy AT gnshuev appliedaspectsofslco1b1pharmacogenetictestingforpredictingofstatininducedmyopathyandpersonalizationofstatinstherapy AT abprokofiev appliedaspectsofslco1b1pharmacogenetictestingforpredictingofstatininducedmyopathyandpersonalizationofstatinstherapy |