Diverse cellular strategies for the export of leaderless proteins
Unconventional protein export/secretion (UPE/UPS), in contrast to the classical ER-Golgi-dependent export/secretion of proteins with a leader sequence (signal peptide), employs multiple means to release leaderless cargoes (and in some special cases, cargoes with a leader sequence) to the extracellul...
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| Language: | English |
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Science Press
2022-08-01
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| Series: | National Science Open |
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| Online Access: | https://www.sciengine.com/doi/10.1360/nso/20220018 |
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| _version_ | 1850074775655809024 |
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| author | Zheng Jianfei Ge Liang |
| author_facet | Zheng Jianfei Ge Liang |
| author_sort | Zheng Jianfei |
| collection | DOAJ |
| description | Unconventional protein export/secretion (UPE/UPS), in contrast to the classical ER-Golgi-dependent export/secretion of proteins with a leader sequence (signal peptide), employs multiple means to release leaderless cargoes (and in some special cases, cargoes with a leader sequence) to the extracellular space. By far, two major types of UPE have been classified, vesicle-independent UPE and vesicle-dependent UPE. In the former, UPE cargoes can directly translocate across the plasma membrane from the cytoplasm without the assistance of a vesicle carrier. In the latter, UPE cargoes translocate into the lumen of a vesicle which then delivers them out of the cell through membrane trafficking. Both types of UPE require multiple unconventional solutions to complete secretion. Here, we briefly discuss the multiple strategies for a UPE cargo release, focusing on two key steps of leaderless cargoes release in UPE: protein translocation and membrane trafficking. |
| format | Article |
| id | doaj-art-a4f6d16bab5b488c83ed2b533c2c5206 |
| institution | DOAJ |
| issn | 2097-1168 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Science Press |
| record_format | Article |
| series | National Science Open |
| spelling | doaj-art-a4f6d16bab5b488c83ed2b533c2c52062025-08-20T02:46:29ZengScience PressNational Science Open2097-11682022-08-01110.1360/nso/20220018eb33e642Diverse cellular strategies for the export of leaderless proteinsZheng Jianfei0Ge Liang1[][]Unconventional protein export/secretion (UPE/UPS), in contrast to the classical ER-Golgi-dependent export/secretion of proteins with a leader sequence (signal peptide), employs multiple means to release leaderless cargoes (and in some special cases, cargoes with a leader sequence) to the extracellular space. By far, two major types of UPE have been classified, vesicle-independent UPE and vesicle-dependent UPE. In the former, UPE cargoes can directly translocate across the plasma membrane from the cytoplasm without the assistance of a vesicle carrier. In the latter, UPE cargoes translocate into the lumen of a vesicle which then delivers them out of the cell through membrane trafficking. Both types of UPE require multiple unconventional solutions to complete secretion. Here, we briefly discuss the multiple strategies for a UPE cargo release, focusing on two key steps of leaderless cargoes release in UPE: protein translocation and membrane trafficking.https://www.sciengine.com/doi/10.1360/nso/20220018secretionGSDMDIL-1unconventional protein secretiontranslocationERGICautophagosomemulti-vesicular bodylysosomevesicle transportFGF2 |
| spellingShingle | Zheng Jianfei Ge Liang Diverse cellular strategies for the export of leaderless proteins National Science Open secretion GSDMD IL-1 unconventional protein secretion translocation ERGIC autophagosome multi-vesicular body lysosome vesicle transport FGF2 |
| title | Diverse cellular strategies for the export of leaderless proteins |
| title_full | Diverse cellular strategies for the export of leaderless proteins |
| title_fullStr | Diverse cellular strategies for the export of leaderless proteins |
| title_full_unstemmed | Diverse cellular strategies for the export of leaderless proteins |
| title_short | Diverse cellular strategies for the export of leaderless proteins |
| title_sort | diverse cellular strategies for the export of leaderless proteins |
| topic | secretion GSDMD IL-1 unconventional protein secretion translocation ERGIC autophagosome multi-vesicular body lysosome vesicle transport FGF2 |
| url | https://www.sciengine.com/doi/10.1360/nso/20220018 |
| work_keys_str_mv | AT zhengjianfei diversecellularstrategiesfortheexportofleaderlessproteins AT geliang diversecellularstrategiesfortheexportofleaderlessproteins |