Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

Abstract The emergence of various SARS-CoV-2 variants presents challenges for antibody therapeutics, emphasizing the need for more potent and broadly neutralizing antibodies. Here, we employed an unbiased screening approach and successfully isolated two antibodies from individuals with only exposure...

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Main Authors: Lei Yu, Yajie Wang, Yuanchen Liu, Xiaomin Xing, Chen Li, Xun Wang, Jialu Shi, Wentai Ma, Jiayan Li, Yanjia Chen, Rui Qiao, Xiaoyu Zhao, Shilei Tian, Ming Gao, Shuhua Wen, Yingxue Xue, Tianyi Qiu, Hongjie Yu, Yongjun Guan, Hin Chu, Lei Sun, Pengfei Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07769-7
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