SIRT5 inhibits glycolysis and nasal type extranodal NK/T cell lymphoma cell proliferation by catalyzing the desuccinylation of glucose-6-phosphate isomerase

SIRT5 inhibits glycolysis and nasal type extranodal NK/T cell lymphoma cell proliferation by catalyzing the desuccinylation of glucose-6-phosphate isomerase

Background: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a malignant tumor harboring a poor prognosis and unsatisfactory treatment outcomes. This study was performed to explore the pathogenesis and exact etiology of ENKTL. Methods Bioinformatic analysis was conducted to investiga...

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Bibliographic Details
Main Authors: Tiansheng Wang, Guolin Tan, Ming Jiang, Guohui Liu, Wei Li, Xiang Qing
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Translational Oncology
Subjects:
ENKTL
SIRT5
GPI
Glycolysis
Desuccinylation
Cell proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523324003425
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