Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders
Identifying novel biomarkers is a reliable approach to predict and diagnose human diseases as well as manage individual responses to therapeutic drugs. Heat shock proteins (HSPs) are molecular chaperones that play a major role in maintaining protein stability and folding. Many studies suggested thei...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-04-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/5/10.31083/FBL27324 |
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| author | Jyoti Upadhyay Mukesh Nandave Kamal Y. Thajudeen Summya Rashid Mohd Nazam Ansari |
| author_facet | Jyoti Upadhyay Mukesh Nandave Kamal Y. Thajudeen Summya Rashid Mohd Nazam Ansari |
| author_sort | Jyoti Upadhyay |
| collection | DOAJ |
| description | Identifying novel biomarkers is a reliable approach to predict and diagnose human diseases as well as manage individual responses to therapeutic drugs. Heat shock proteins (HSPs) are molecular chaperones that play a major role in maintaining protein stability and folding. Many studies suggested their association with multiple types of diseases. HSPs from different categories play different roles; therefore, it is important to identify HSPs and their function to understand their biological functions clearly. This comprehensive review was performed to evaluate the role of HSPs as predictive biomarkers in cardiovascular diseases. The original publications related to HSPs from 2010 to 2024 were identified by using the keywords “heat-shock proteins”, “HSP in cardiovascular disorders” and “HSP in atherosclerosis”. The regulatory pathways involved in HSPs’ functioning are the important points of discussion in this review. HSPs play a critical role in key cellular processes, including apoptosis regulation, protein folding, immune responses, genomic stability, and DNA repair. Aberrant expression of HSPs causes dysregulation of these pathways resulting in the development and progression of diseases. A comprehensive understanding of HSPs in cardiovascular diseases and their associated regulatory pathways can have significant implications for disease intervention, diagnosis, and prognosis. In this review paper, we have highlighted the importance of HSPs as versatile biomarkers and their importance as targets for the therapeutic management of cardiovascular diseases. |
| format | Article |
| id | doaj-art-a4eb20c51c8f47c68613146d1f84d97f |
| institution | OA Journals |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-a4eb20c51c8f47c68613146d1f84d97f2025-08-20T02:03:00ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-04-013052732410.31083/FBL27324S2768-6701(25)01649-1Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular DisordersJyoti Upadhyay0Mukesh Nandave1Kamal Y. Thajudeen2Summya Rashid3Mohd Nazam Ansari4Department of Pharmaceutical Sciences, School of Health Science and Technology, UPES, Campus Bidholi Dehradun, 248007 Uttarakhand, IndiaDepartment of Pharmacology, Delhi Pharmaceutical Sciences and Research University (DPSRU), 110017 New Delhi, IndiaDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, 62529 Abha, Saudi ArabiaDepartment of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942 Al-Kharj, Saudi ArabiaDepartment of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942 Al-Kharj, Saudi ArabiaIdentifying novel biomarkers is a reliable approach to predict and diagnose human diseases as well as manage individual responses to therapeutic drugs. Heat shock proteins (HSPs) are molecular chaperones that play a major role in maintaining protein stability and folding. Many studies suggested their association with multiple types of diseases. HSPs from different categories play different roles; therefore, it is important to identify HSPs and their function to understand their biological functions clearly. This comprehensive review was performed to evaluate the role of HSPs as predictive biomarkers in cardiovascular diseases. The original publications related to HSPs from 2010 to 2024 were identified by using the keywords “heat-shock proteins”, “HSP in cardiovascular disorders” and “HSP in atherosclerosis”. The regulatory pathways involved in HSPs’ functioning are the important points of discussion in this review. HSPs play a critical role in key cellular processes, including apoptosis regulation, protein folding, immune responses, genomic stability, and DNA repair. Aberrant expression of HSPs causes dysregulation of these pathways resulting in the development and progression of diseases. A comprehensive understanding of HSPs in cardiovascular diseases and their associated regulatory pathways can have significant implications for disease intervention, diagnosis, and prognosis. In this review paper, we have highlighted the importance of HSPs as versatile biomarkers and their importance as targets for the therapeutic management of cardiovascular diseases.https://www.imrpress.com/journal/FBL/30/5/10.31083/FBL27324heat shock proteincardiovascular diseasesatherosclerosispredictive biomarker |
| spellingShingle | Jyoti Upadhyay Mukesh Nandave Kamal Y. Thajudeen Summya Rashid Mohd Nazam Ansari Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders Frontiers in Bioscience-Landmark heat shock protein cardiovascular diseases atherosclerosis predictive biomarker |
| title | Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders |
| title_full | Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders |
| title_fullStr | Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders |
| title_full_unstemmed | Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders |
| title_short | Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders |
| title_sort | molecular mechanisms and therapeutic targeting of heat shock proteins hsps in cardiovascular disorders |
| topic | heat shock protein cardiovascular diseases atherosclerosis predictive biomarker |
| url | https://www.imrpress.com/journal/FBL/30/5/10.31083/FBL27324 |
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