Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation
IntroductionAcute stroke (AS) is a major public health issue globally, exhibiting high morbidity, disability rate, and mortality. Emerging research has demonstrated the critical roles of gut microbiota and its metabolites in pathogenesis, recovery, and prognosis of AS.MethodsIn this study, we invest...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1580231/full |
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| author | Jiajing Chen Xiaodan Wu Xintong Wang Ruijia Yuan Qi Zhu |
| author_facet | Jiajing Chen Xiaodan Wu Xintong Wang Ruijia Yuan Qi Zhu |
| author_sort | Jiajing Chen |
| collection | DOAJ |
| description | IntroductionAcute stroke (AS) is a major public health issue globally, exhibiting high morbidity, disability rate, and mortality. Emerging research has demonstrated the critical roles of gut microbiota and its metabolites in pathogenesis, recovery, and prognosis of AS.MethodsIn this study, we investigated alterations in gut microbiota composition and metabolomic profiles in AS patients using 16S rRNA sequencing and untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics technology.ResultsThe results revealed significant changes in gut microbiota diversity and community structure in AS patients compared with healthy controls. Notably, the abundance of anti-inflammatory microbiota was increased significantly, accompanied by elevated levels of certain metabolites, such as 6,9,12,15,18,21-tetracosahexaenoic acid and bufadienolide, while levels of urobilin and andrenid acid were significantly reduced. Network analysis further uncovered the significant diferences in microbiota-metabolite interactions between AS patients and healthy controls, indicating gut ecosystem disruption and functional dysfunction in AS.DiscussionThis study sheds light on the mechanisms of brain-gut axis in AS, suggesting potential microbial and metabolite biomarkers, thus providing valuable insights into AS prediction and treatment. |
| format | Article |
| id | doaj-art-a4e6c58feec5402bb7994749e826b985 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-a4e6c58feec5402bb7994749e826b9852025-08-22T05:26:58ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-08-011610.3389/fmicb.2025.15802311580231Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulationJiajing Chen0Xiaodan Wu1Xintong Wang2Ruijia Yuan3Qi Zhu4Emergency Department, Central Hospital Affiliated to Shenyang Medical College, Shenyang, ChinaEmergency Department, Central Hospital Affiliated to Shenyang Medical College, Shenyang, ChinaSchool of Clinical Medicine, China Medical University, Shenyang, ChinaSchool of Nursing, China Medical University, Shenyang, ChinaEmergency Department, Central Hospital Affiliated to Shenyang Medical College, Shenyang, ChinaIntroductionAcute stroke (AS) is a major public health issue globally, exhibiting high morbidity, disability rate, and mortality. Emerging research has demonstrated the critical roles of gut microbiota and its metabolites in pathogenesis, recovery, and prognosis of AS.MethodsIn this study, we investigated alterations in gut microbiota composition and metabolomic profiles in AS patients using 16S rRNA sequencing and untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics technology.ResultsThe results revealed significant changes in gut microbiota diversity and community structure in AS patients compared with healthy controls. Notably, the abundance of anti-inflammatory microbiota was increased significantly, accompanied by elevated levels of certain metabolites, such as 6,9,12,15,18,21-tetracosahexaenoic acid and bufadienolide, while levels of urobilin and andrenid acid were significantly reduced. Network analysis further uncovered the significant diferences in microbiota-metabolite interactions between AS patients and healthy controls, indicating gut ecosystem disruption and functional dysfunction in AS.DiscussionThis study sheds light on the mechanisms of brain-gut axis in AS, suggesting potential microbial and metabolite biomarkers, thus providing valuable insights into AS prediction and treatment.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1580231/fullacute strokegut microbiotametabolomicsbrain-gut axisbiomarkers |
| spellingShingle | Jiajing Chen Xiaodan Wu Xintong Wang Ruijia Yuan Qi Zhu Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation Frontiers in Microbiology acute stroke gut microbiota metabolomics brain-gut axis biomarkers |
| title | Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation |
| title_full | Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation |
| title_fullStr | Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation |
| title_full_unstemmed | Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation |
| title_short | Alterations in gut microbiota and metabolomic profiles in acute stroke: insights into brain–gut axis dysregulation |
| title_sort | alterations in gut microbiota and metabolomic profiles in acute stroke insights into brain gut axis dysregulation |
| topic | acute stroke gut microbiota metabolomics brain-gut axis biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1580231/full |
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