Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers

Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers

Abstract Background Exercising with low muscle glycogen content can improve training adaptation, but the mechanisms underlying the muscular adaptation are still largely unknown. In this study, we measured substrate utilization and cell signaling in different muscle fiber types during exercise and in...

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Bibliographic Details
Main Authors: Oscar Horwath, Lucas Cornet, Henrik Strömlind, Marcus Moberg, Sebastian Edman, Karin Söderlund, Antonio Checa, Jorge L. Ruas, Eva Blomstrand
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Skeletal Muscle
Subjects:
Autophagy
Muscle fiber type
mTORC1
Fatty acids
Metabolomics
Online Access:https://doi.org/10.1186/s13395-025-00377-3
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