A systematic review of the association between insulin resistance surrogate indices and bone mineral density
BackgroundThe relationship of insulin resistance with bone mineral density (BMD) remains unclear, offering an opportunity for novel indices to shed light on the matter. The aim of this review was to evaluate the association between surrogate indices of insulin resistance and BMD.MethodsA systematic...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1499479/full |
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| author | Amirhossein Shirinezhad Alireza Azarboo Amirhossein Ghaseminejad-Raeini Fatemeh Kanaani Nejad Negar Zareshahi Sheyda Mohtasham Amiri Yasamin Tahmasebi Amir Human Hoveidaei |
| author_facet | Amirhossein Shirinezhad Alireza Azarboo Amirhossein Ghaseminejad-Raeini Fatemeh Kanaani Nejad Negar Zareshahi Sheyda Mohtasham Amiri Yasamin Tahmasebi Amir Human Hoveidaei |
| author_sort | Amirhossein Shirinezhad |
| collection | DOAJ |
| description | BackgroundThe relationship of insulin resistance with bone mineral density (BMD) remains unclear, offering an opportunity for novel indices to shed light on the matter. The aim of this review was to evaluate the association between surrogate indices of insulin resistance and BMD.MethodsA systematic review was conducted to evaluate observational studies that examined the relationship between insulin resistance surrogate indices and BMD in adults. Databases including PubMed, Web of Science, Scopus, and Embase were searched. Quality assessment was performed using Joanna Briggs Institute (JBI) critical appraisal tools.ResultsThis systematic review included 27 cohorts and cross-sectional studies with 71,525 participants to assess the potential link between insulin resistance surrogate indices like HOMA-IR, HOMA-β, TyG, TyG-BMI, TyG-WtHR, and TyG-WC, along with METS-IR, and VAI, and BMD at various sites. There seems to be no link between BMD and the HOMA index, despite being extensively studied in various studies (adjusted β ranging from -0.49 to 0.103). Most literature suggests that a higher TyG index is associated with decreased BMD levels (adjusted β ranging from -0.085 to 0.0124). Despite limited evidence, other insulin resistance indices such as VAI (adjusted β ranging from 0.007 to 0.016), TyG-BMI (adjusted β ranging from 0.002 to 0.415), METS-IR (adjusted β ranging from 0.005 to 0.060), TyG-WtHR (β = 0.012) and TyG-WC (β = 0.0001) have shown a positive association with BMD in a few studies.ConclusionThis systematic review emphasizes the intricate connection between insulin resistance and BMD. The lack of ability to perform a meta-analysis and the dependence on cross-sectional studies hinder the robustness of the findings, hence necessitating well-designed longitudinal studies.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024512770. |
| format | Article |
| id | doaj-art-a4e4cbcc12a04a25aa94a8f000fd1151 |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-a4e4cbcc12a04a25aa94a8f000fd11512025-08-20T01:58:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.14994791499479A systematic review of the association between insulin resistance surrogate indices and bone mineral densityAmirhossein Shirinezhad0Alireza Azarboo1Amirhossein Ghaseminejad-Raeini2Fatemeh Kanaani Nejad3Negar Zareshahi4Sheyda Mohtasham Amiri5Yasamin Tahmasebi6Amir Human Hoveidaei7School of Medicine, Tehran University of Medical Sciences, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranMedical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Medicine, Islamic Azad University Tehran Medical Sciences, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranSports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, IranBackgroundThe relationship of insulin resistance with bone mineral density (BMD) remains unclear, offering an opportunity for novel indices to shed light on the matter. The aim of this review was to evaluate the association between surrogate indices of insulin resistance and BMD.MethodsA systematic review was conducted to evaluate observational studies that examined the relationship between insulin resistance surrogate indices and BMD in adults. Databases including PubMed, Web of Science, Scopus, and Embase were searched. Quality assessment was performed using Joanna Briggs Institute (JBI) critical appraisal tools.ResultsThis systematic review included 27 cohorts and cross-sectional studies with 71,525 participants to assess the potential link between insulin resistance surrogate indices like HOMA-IR, HOMA-β, TyG, TyG-BMI, TyG-WtHR, and TyG-WC, along with METS-IR, and VAI, and BMD at various sites. There seems to be no link between BMD and the HOMA index, despite being extensively studied in various studies (adjusted β ranging from -0.49 to 0.103). Most literature suggests that a higher TyG index is associated with decreased BMD levels (adjusted β ranging from -0.085 to 0.0124). Despite limited evidence, other insulin resistance indices such as VAI (adjusted β ranging from 0.007 to 0.016), TyG-BMI (adjusted β ranging from 0.002 to 0.415), METS-IR (adjusted β ranging from 0.005 to 0.060), TyG-WtHR (β = 0.012) and TyG-WC (β = 0.0001) have shown a positive association with BMD in a few studies.ConclusionThis systematic review emphasizes the intricate connection between insulin resistance and BMD. The lack of ability to perform a meta-analysis and the dependence on cross-sectional studies hinder the robustness of the findings, hence necessitating well-designed longitudinal studies.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024512770.https://www.frontiersin.org/articles/10.3389/fendo.2024.1499479/fullinsulin resistancebone mineral densityHOMA-IRTyG indexVAIsystematic review |
| spellingShingle | Amirhossein Shirinezhad Alireza Azarboo Amirhossein Ghaseminejad-Raeini Fatemeh Kanaani Nejad Negar Zareshahi Sheyda Mohtasham Amiri Yasamin Tahmasebi Amir Human Hoveidaei A systematic review of the association between insulin resistance surrogate indices and bone mineral density Frontiers in Endocrinology insulin resistance bone mineral density HOMA-IR TyG index VAI systematic review |
| title | A systematic review of the association between insulin resistance surrogate indices and bone mineral density |
| title_full | A systematic review of the association between insulin resistance surrogate indices and bone mineral density |
| title_fullStr | A systematic review of the association between insulin resistance surrogate indices and bone mineral density |
| title_full_unstemmed | A systematic review of the association between insulin resistance surrogate indices and bone mineral density |
| title_short | A systematic review of the association between insulin resistance surrogate indices and bone mineral density |
| title_sort | systematic review of the association between insulin resistance surrogate indices and bone mineral density |
| topic | insulin resistance bone mineral density HOMA-IR TyG index VAI systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1499479/full |
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