Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges

Bacterial meningitis (BM) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality. The most common cases of BM around the world, mainly in Brazil, have been caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influen...

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Main Authors: Maristela Marques Salgado, Maria Gisele Goncalves, Lucila Okuyama Fukasawa, Fabio Takenori Higa, Juliana Thalita Paulino, Claudio Tavares Sacchi
Format: Article
Language:English
Published: Thieme Revinter Publicações 2013-09-01
Series:Arquivos de Neuro-Psiquiatria
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Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000672&lng=en&tlng=en
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author Maristela Marques Salgado
Maria Gisele Goncalves
Lucila Okuyama Fukasawa
Fabio Takenori Higa
Juliana Thalita Paulino
Claudio Tavares Sacchi
author_facet Maristela Marques Salgado
Maria Gisele Goncalves
Lucila Okuyama Fukasawa
Fabio Takenori Higa
Juliana Thalita Paulino
Claudio Tavares Sacchi
author_sort Maristela Marques Salgado
collection DOAJ
description Bacterial meningitis (BM) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality. The most common cases of BM around the world, mainly in Brazil, have been caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b. Bacterial culture is the gold-standard technique for BM confirmation, but approximately 50% of suspected cases are not culture-confirmed, due to problems related to improper transportation and seeding or previous antibiotic treatment. Immunological methods present low sensitivity and have possibility of cross-reactions. Real time PCR (qPCR) is a molecular technique and has been successful used for BM diagnosis at Instituto Adolfo Lutz in São Paulo State, Brazil, since 2007. The incorporation of qPCR in the Public Health surveillance routine in our state resulted in diminishing 50% of undetermined BM cases. Our efforts are focused on qPCR implementation in the BM diagnostic routine throughout Brazil.
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issn 1678-4227
language English
publishDate 2013-09-01
publisher Thieme Revinter Publicações
record_format Article
series Arquivos de Neuro-Psiquiatria
spelling doaj-art-a4e3b1f949b644f2a866afb60b06c7952025-08-20T03:18:59ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272013-09-01719B67267610.1590/0004-282X20130148S0004-282X2013001000672Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challengesMaristela Marques SalgadoMaria Gisele GoncalvesLucila Okuyama FukasawaFabio Takenori HigaJuliana Thalita PaulinoClaudio Tavares SacchiBacterial meningitis (BM) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality. The most common cases of BM around the world, mainly in Brazil, have been caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b. Bacterial culture is the gold-standard technique for BM confirmation, but approximately 50% of suspected cases are not culture-confirmed, due to problems related to improper transportation and seeding or previous antibiotic treatment. Immunological methods present low sensitivity and have possibility of cross-reactions. Real time PCR (qPCR) is a molecular technique and has been successful used for BM diagnosis at Instituto Adolfo Lutz in São Paulo State, Brazil, since 2007. The incorporation of qPCR in the Public Health surveillance routine in our state resulted in diminishing 50% of undetermined BM cases. Our efforts are focused on qPCR implementation in the BM diagnostic routine throughout Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000672&lng=en&tlng=enBacterial meningitismolecular diagnosisreal time PCRMeningite bacterianadiagnostico molecularPCR em tempo real
spellingShingle Maristela Marques Salgado
Maria Gisele Goncalves
Lucila Okuyama Fukasawa
Fabio Takenori Higa
Juliana Thalita Paulino
Claudio Tavares Sacchi
Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges
Arquivos de Neuro-Psiquiatria
Bacterial meningitis
molecular diagnosis
real time PCR
Meningite bacteriana
diagnostico molecular
PCR em tempo real
title Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges
title_full Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges
title_fullStr Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges
title_full_unstemmed Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges
title_short Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges
title_sort evolution of bacterial meningitis diagnosis in sao paulo state brazil and future challenges
topic Bacterial meningitis
molecular diagnosis
real time PCR
Meningite bacteriana
diagnostico molecular
PCR em tempo real
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000672&lng=en&tlng=en
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