PRDM16 acts as a homeostasis regulation factor to suppress the transition of AKI to CKD via upregulation of eukaryotic initiation factor 6

PRDM16 acts as a homeostasis regulation factor to suppress the transition of AKI to CKD via upregulation of eukaryotic initiation factor 6

Abstract Progressing from acute kidney injury (AKI) to chronic kidney disease (CKD) is acknowledged as a significant clinical challenge. Our recent works indicated that PR domain-containing 16 (PRDM16) impedes the progression of AKI and DKD. Nonetheless, the specific function and regulatory mechanis...

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Bibliographic Details
Main Authors: Xiaozhou Li, Yang Xia, Xingjin Li, Yong Guo, Shuangfa Qiu, Huiling Li, Yijian Li, Lidong Wu, Dongshan Zhang
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
AKI
PRDM16
CKD
eIF6
Online Access:https://doi.org/10.1007/s00018-025-05766-x
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