The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised tissue abilities to protect the heart against stre...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/7953486 |
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| author | Laura Iop Eleonora Dal Sasso Leonardo Schirone Maurizio Forte Mariangela Peruzzi Elena Cavarretta Silvia Palmerio Gino Gerosa Sebastiano Sciarretta Giacomo Frati |
| author_facet | Laura Iop Eleonora Dal Sasso Leonardo Schirone Maurizio Forte Mariangela Peruzzi Elena Cavarretta Silvia Palmerio Gino Gerosa Sebastiano Sciarretta Giacomo Frati |
| author_sort | Laura Iop |
| collection | DOAJ |
| description | Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised tissue abilities to protect the heart against stress. At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis. In this review, we explore the intrinsic and extrinsic causes of cellular senescence and their role in the onset of these cardiovascular pathologies. Additionally, we dissect the effects of aging on the cardiac endogenous and exogenous reservoirs of stem cells. Finally, we offer an overview on the strategies of regenerative medicine that have been advanced in the quest for heart rejuvenation. |
| format | Article |
| id | doaj-art-a4e12d80ea3d459a8d5525eedd4f1b77 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-a4e12d80ea3d459a8d5525eedd4f1b772025-02-03T05:51:53ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/79534867953486The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative MedicineLaura Iop0Eleonora Dal Sasso1Leonardo Schirone2Maurizio Forte3Mariangela Peruzzi4Elena Cavarretta5Silvia Palmerio6Gino Gerosa7Sebastiano Sciarretta8Giacomo Frati9Cardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua and Venetian Institute of Molecular Medicine, Padua, ItalyCardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua and Venetian Institute of Molecular Medicine, Padua, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, ItalyIRCCS Neuromed, Pozzilli, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, ItalyCardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua and Venetian Institute of Molecular Medicine, Padua, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, ItalyRecent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised tissue abilities to protect the heart against stress. At the molecular level, in fact, a gradual weakening of the cellular processes regulating cardiovascular homeostasis occurs in aging cells. Atherosclerosis and heart failure are particularly correlated with aging-related cardiovascular senescence, that is, the inability of cells to progress in the mitotic program until completion of cytokinesis. In this review, we explore the intrinsic and extrinsic causes of cellular senescence and their role in the onset of these cardiovascular pathologies. Additionally, we dissect the effects of aging on the cardiac endogenous and exogenous reservoirs of stem cells. Finally, we offer an overview on the strategies of regenerative medicine that have been advanced in the quest for heart rejuvenation.http://dx.doi.org/10.1155/2017/7953486 |
| spellingShingle | Laura Iop Eleonora Dal Sasso Leonardo Schirone Maurizio Forte Mariangela Peruzzi Elena Cavarretta Silvia Palmerio Gino Gerosa Sebastiano Sciarretta Giacomo Frati The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine Mediators of Inflammation |
| title | The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine |
| title_full | The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine |
| title_fullStr | The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine |
| title_full_unstemmed | The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine |
| title_short | The Light and Shadow of Senescence and Inflammation in Cardiovascular Pathology and Regenerative Medicine |
| title_sort | light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine |
| url | http://dx.doi.org/10.1155/2017/7953486 |
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