Rapamycin reduces DNA damage of in vitro matured oocytes by promoting Rad51-mediated homologous recombination

Rapamycin reduces DNA damage of in vitro matured oocytes by promoting Rad51-mediated homologous recombination

Abstract Background The quality of in vitro matured (IVM) oocytes remains inferior to that of in vivo matured oocytes, likely due to DNA damage induced by the in vitro environment. Although rapamycin has been shown to improve the developmental competence of IVM oocytes by reducing DNA double-strand...

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Bibliographic Details
Main Authors: Qiyu Yang, Ying Chen, Jiayu Huang, Junying Tang, Lixia Zhu, Jingyu Li, Chao Tong
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
Rapamycin
In vitro maturation
Oocyte
DNA damage
Homologous recombination
Online Access:https://doi.org/10.1186/s12958-025-01428-6
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