Matrix stiffness enhances viability, migration, invasion and invadopodia formation of oral cancer cells via PI3K/AKT pathway in vitro

Matrix stiffness enhances viability, migration, invasion and invadopodia formation of oral cancer cells via PI3K/AKT pathway in vitro

Abstract Background Oral cancer (OC) is one of the major types of cancer and the most common cause of cancer-related mortality in Asia. In recent years, matrix stiffness in the tumor microenvironment has been found to play an important role in regulating tumor cell behavior. However, the regulatory...

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Bibliographic Details
Main Authors: Zihao Zhang, Jiayi Ren, Ke Tang, Xinyi Hu, Jinhui Liu, Chunming Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:European Journal of Medical Research
Subjects:
Matrix stiffness
Oral cancer
Metastasis
Invadopodia
PI3K/AKT pathway
Online Access:https://doi.org/10.1186/s40001-025-02666-5
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