Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis
Abstract Background The apolipoprotein E ε4 (APOE ε4) status has a controversial role in predicting Alzheimer’s disease (AD) factors. This meta-analysis assessed AD event risk in patients with APOE ε4 status. Materials and methods The relevant English-language articles were identified by searching t...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Neuroscience |
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| Online Access: | https://doi.org/10.1186/s12868-024-00914-8 |
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| _version_ | 1832586007225040896 |
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| author | Zijun Ren Zhenting Guan Qingliang Guan Hongjian Guan Hongjian Guan |
| author_facet | Zijun Ren Zhenting Guan Qingliang Guan Hongjian Guan Hongjian Guan |
| author_sort | Zijun Ren |
| collection | DOAJ |
| description | Abstract Background The apolipoprotein E ε4 (APOE ε4) status has a controversial role in predicting Alzheimer’s disease (AD) factors. This meta-analysis assessed AD event risk in patients with APOE ε4 status. Materials and methods The relevant English-language articles were identified by searching the Cochrane Library, EMBASE, and PubMed databases. The prognostic significance of APOE ε4 status in AD patients was examined on the basis of pooled hazard ratios (HRs). Results A total of 22 studies published after 1987, including 571,800 patients, were included. Consequently, APOE ε4 status was a risk factor for disease-free survival (DFS, HR = 2.033; 95% confidence interval [CI] = 1.589–2.602; P = 0.000; I 2 = 93.1%) in patients with AD. Additionally, subgroup analysis suggested that the ROC curve was the main risk factor among patients with AD. Conclusions AD patients with different events are managed via different methods; however, the present meta-analysis suggests an increased risk of AD events in patients with different APOE ε4 statuses. |
| format | Article |
| id | doaj-art-a4d95a57672946cc871a95c1c9e373d4 |
| institution | Kabale University |
| issn | 1471-2202 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj-art-a4d95a57672946cc871a95c1c9e373d42025-01-26T12:16:51ZengBMCBMC Neuroscience1471-22022025-01-012611910.1186/s12868-024-00914-8Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysisZijun Ren0Zhenting Guan1Qingliang Guan2Hongjian Guan3Hongjian Guan4Department of Neurology, Yanbian University hospitalDepartment of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese MedicineDepartment of Neurosurgery, City of Zhucheng, Zhucheng Hospital of Chinese MedicineDepartment of Neurology, Yanbian University hospitalDepartment of General Medicine, Yanbian University HospitalAbstract Background The apolipoprotein E ε4 (APOE ε4) status has a controversial role in predicting Alzheimer’s disease (AD) factors. This meta-analysis assessed AD event risk in patients with APOE ε4 status. Materials and methods The relevant English-language articles were identified by searching the Cochrane Library, EMBASE, and PubMed databases. The prognostic significance of APOE ε4 status in AD patients was examined on the basis of pooled hazard ratios (HRs). Results A total of 22 studies published after 1987, including 571,800 patients, were included. Consequently, APOE ε4 status was a risk factor for disease-free survival (DFS, HR = 2.033; 95% confidence interval [CI] = 1.589–2.602; P = 0.000; I 2 = 93.1%) in patients with AD. Additionally, subgroup analysis suggested that the ROC curve was the main risk factor among patients with AD. Conclusions AD patients with different events are managed via different methods; however, the present meta-analysis suggests an increased risk of AD events in patients with different APOE ε4 statuses.https://doi.org/10.1186/s12868-024-00914-8APOE ε4 statusAlzheimer’s diseasePrognosisMeta-analysis |
| spellingShingle | Zijun Ren Zhenting Guan Qingliang Guan Hongjian Guan Hongjian Guan Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis BMC Neuroscience APOE ε4 status Alzheimer’s disease Prognosis Meta-analysis |
| title | Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis |
| title_full | Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis |
| title_fullStr | Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis |
| title_full_unstemmed | Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis |
| title_short | Association between apolipoprotein E ε4 status and the risk of Alzheimer’s disease: a meta-analysis |
| title_sort | association between apolipoprotein e ε4 status and the risk of alzheimer s disease a meta analysis |
| topic | APOE ε4 status Alzheimer’s disease Prognosis Meta-analysis |
| url | https://doi.org/10.1186/s12868-024-00914-8 |
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