Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis.
<h4>Objective</h4>The current study was designed to evaluate the sensitivity, feasibility, and effectiveness of the pallidal index (PI) serving as a biomarker of brain manganese (Mn) accumulation, which would be used as an early diagnosis criteria for Mn neurotoxicity.<h4>Methods&l...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093900&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850026414272675840 |
|---|---|
| author | Shao-Jun Li Li Jiang Xue Fu Shuang Huang Yan-Ni Huang Xiang-Rong Li Jing-Wen Chen Yong Li Hai-Lan Luo Fang Wang Shi-Yan Ou Yue-Ming Jiang |
| author_facet | Shao-Jun Li Li Jiang Xue Fu Shuang Huang Yan-Ni Huang Xiang-Rong Li Jing-Wen Chen Yong Li Hai-Lan Luo Fang Wang Shi-Yan Ou Yue-Ming Jiang |
| author_sort | Shao-Jun Li |
| collection | DOAJ |
| description | <h4>Objective</h4>The current study was designed to evaluate the sensitivity, feasibility, and effectiveness of the pallidal index (PI) serving as a biomarker of brain manganese (Mn) accumulation, which would be used as an early diagnosis criteria for Mn neurotoxicity.<h4>Methods</h4>The weighted mean difference (WMD) of the PI between control and Mn-exposed groups was estimated by using a random-effects or fixed-effects meta-analysis with 95% confidence interval (CI) performed by STATA software version 12.1. Moreover, the R package "metacor" was used to estimate correlation coefficients between PI and blood Mn (MnB).<h4>Results</h4>A total of eight studies with 281 occupationally Mn-exposed workers met the inclusion criteria. Results were pooled and performed with the Meta-analysis. Our data indicated that the PI of the exposed group was significantly higher than that of the control (WMD: 7.76; 95% CI: 4.86, 10.65; I2 = 85.7%, p<0.0001). A random effects model was used to perform meta-analysis. These findings were remarkably robust in the sensitivity analysis, and publication bias was shown in the included studies. Seven out of the eight studies reported the Pearson correlation (r) values. Significantly positive correlation between PI and MnB was observed (r = 0.42; 95% CI, 0.31, 0.52).<h4>Conclusions</h4>PI can be considered as a sensitive, feasible, effective and semi-quantitative index in evaluating brain Mn accumulation. MnB can also augment the evaluation of brain Mn accumulation levels in the near future. However, the results should be interpreted with caution. |
| format | Article |
| id | doaj-art-a4d3252b70584be79cb3cfc4cf374d95 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-a4d3252b70584be79cb3cfc4cf374d952025-08-20T03:00:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9390010.1371/journal.pone.0093900Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis.Shao-Jun LiLi JiangXue FuShuang HuangYan-Ni HuangXiang-Rong LiJing-Wen ChenYong LiHai-Lan LuoFang WangShi-Yan OuYue-Ming Jiang<h4>Objective</h4>The current study was designed to evaluate the sensitivity, feasibility, and effectiveness of the pallidal index (PI) serving as a biomarker of brain manganese (Mn) accumulation, which would be used as an early diagnosis criteria for Mn neurotoxicity.<h4>Methods</h4>The weighted mean difference (WMD) of the PI between control and Mn-exposed groups was estimated by using a random-effects or fixed-effects meta-analysis with 95% confidence interval (CI) performed by STATA software version 12.1. Moreover, the R package "metacor" was used to estimate correlation coefficients between PI and blood Mn (MnB).<h4>Results</h4>A total of eight studies with 281 occupationally Mn-exposed workers met the inclusion criteria. Results were pooled and performed with the Meta-analysis. Our data indicated that the PI of the exposed group was significantly higher than that of the control (WMD: 7.76; 95% CI: 4.86, 10.65; I2 = 85.7%, p<0.0001). A random effects model was used to perform meta-analysis. These findings were remarkably robust in the sensitivity analysis, and publication bias was shown in the included studies. Seven out of the eight studies reported the Pearson correlation (r) values. Significantly positive correlation between PI and MnB was observed (r = 0.42; 95% CI, 0.31, 0.52).<h4>Conclusions</h4>PI can be considered as a sensitive, feasible, effective and semi-quantitative index in evaluating brain Mn accumulation. MnB can also augment the evaluation of brain Mn accumulation levels in the near future. However, the results should be interpreted with caution.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093900&type=printable |
| spellingShingle | Shao-Jun Li Li Jiang Xue Fu Shuang Huang Yan-Ni Huang Xiang-Rong Li Jing-Wen Chen Yong Li Hai-Lan Luo Fang Wang Shi-Yan Ou Yue-Ming Jiang Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis. PLoS ONE |
| title | Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis. |
| title_full | Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis. |
| title_fullStr | Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis. |
| title_full_unstemmed | Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis. |
| title_short | Pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood: a meta-analysis. |
| title_sort | pallidal index as biomarker of manganese brain accumulation and associated with manganese levels in blood a meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093900&type=printable |
| work_keys_str_mv | AT shaojunli pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT lijiang pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT xuefu pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT shuanghuang pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT yannihuang pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT xiangrongli pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT jingwenchen pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT yongli pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT hailanluo pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT fangwang pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT shiyanou pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis AT yuemingjiang pallidalindexasbiomarkerofmanganesebrainaccumulationandassociatedwithmanganeselevelsinbloodametaanalysis |