Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
In the study performed in a group of patients infected with T. gondii, we evaluated Th2 humoral response (IL-5, IL-6, IL-10) and Th1 cell response (IL-12, TNF-α). The study objective was to assess the effect of T. gondii on chos...
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| Format: | Article |
| Language: | English |
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2009-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2009/374696 |
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| author | Joanna Matowicka-Karna Violetta Dymicka-Piekarska Halina Kemona |
| author_facet | Joanna Matowicka-Karna Violetta Dymicka-Piekarska Halina Kemona |
| author_sort | Joanna Matowicka-Karna |
| collection | DOAJ |
| description | In the study performed in a group of patients infected with
T. gondii, we evaluated Th2 humoral response
(IL-5, IL-6, IL-10) and Th1 cell response (IL-12, TNF-α). The study objective was to assess the effect of
T. gondii on chosen indices of the immune
response. The study involved 52 women infected with
T. gondii (aged 18–42 years) prior to
antiparasitic treatment. In all the patients, we found IgM (index
>0.7) and IgG which exceeded 300 IU/ml. The control
group (C) consisted of 40 healthy women aged 18–46 years. In
the study group (T) and in the control group (C), the levels of
IgE, IL-5, IL-6, IL-10, IL-12, and TNF-α were determined. In our study,
T. gondii patients had twofold higher levels of
IL-5 and IL-6 as compared to healthy subjects, which seems to
confirm the presence of an inflammatory state. We found the level
of IL-10 to be fivefold higher in the course of
toxoplasmosis than in healthy controls. The
levels of IL-12 and TNF-α were comparable to those observed in healthy controls.
The study has revealed that that patients infected with
T. gondii show increased production of the humoral
response cytokines, whereas the generation of the cell response
cytokines remains unchanged. |
| format | Article |
| id | doaj-art-a4d1628f74af4c9caecd560d0aad0dc7 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a4d1628f74af4c9caecd560d0aad0dc72025-02-03T06:01:31ZengWileyClinical and Developmental Immunology1740-25221740-25302009-01-01200910.1155/2009/374696374696Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?Joanna Matowicka-Karna0Violetta Dymicka-Piekarska1Halina Kemona2Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, J. Waszyngton'a 15A, 15-269 Bialystok, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, J. Waszyngton'a 15A, 15-269 Bialystok, PolandDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, J. Waszyngton'a 15A, 15-269 Bialystok, PolandIn the study performed in a group of patients infected with T. gondii, we evaluated Th2 humoral response (IL-5, IL-6, IL-10) and Th1 cell response (IL-12, TNF-α). The study objective was to assess the effect of T. gondii on chosen indices of the immune response. The study involved 52 women infected with T. gondii (aged 18–42 years) prior to antiparasitic treatment. In all the patients, we found IgM (index >0.7) and IgG which exceeded 300 IU/ml. The control group (C) consisted of 40 healthy women aged 18–46 years. In the study group (T) and in the control group (C), the levels of IgE, IL-5, IL-6, IL-10, IL-12, and TNF-α were determined. In our study, T. gondii patients had twofold higher levels of IL-5 and IL-6 as compared to healthy subjects, which seems to confirm the presence of an inflammatory state. We found the level of IL-10 to be fivefold higher in the course of toxoplasmosis than in healthy controls. The levels of IL-12 and TNF-α were comparable to those observed in healthy controls. The study has revealed that that patients infected with T. gondii show increased production of the humoral response cytokines, whereas the generation of the cell response cytokines remains unchanged.http://dx.doi.org/10.1155/2009/374696 |
| spellingShingle | Joanna Matowicka-Karna Violetta Dymicka-Piekarska Halina Kemona Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? Clinical and Developmental Immunology |
| title | Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? |
| title_full | Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? |
| title_fullStr | Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? |
| title_full_unstemmed | Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? |
| title_short | Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)? |
| title_sort | does toxoplasma gondii infection affect the levels of ige and cytokines il 5 il 6 il 10 il 12 and tnf alpha |
| url | http://dx.doi.org/10.1155/2009/374696 |
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