Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer Amphiphiles
Wormlike micelles and vesicles prepared from diblock copolymers are attracting great interest for a number of technological applications. Although transmission electron microscopy has remained as the method of choice for assessing the morphologies, fluorescence microscopy has a number of advantages...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2010/379286 |
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| _version_ | 1850160657841782784 |
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| author | Karthikan Rajagopal David A. Christian Takamasa Harada Aiwei Tian Dennis E. Discher |
| author_facet | Karthikan Rajagopal David A. Christian Takamasa Harada Aiwei Tian Dennis E. Discher |
| author_sort | Karthikan Rajagopal |
| collection | DOAJ |
| description | Wormlike micelles and vesicles prepared from diblock copolymers are attracting great interest for a number of technological applications. Although transmission electron microscopy has remained as the method of choice for assessing the morphologies, fluorescence microscopy has a number of advantages. We show here that when commercially available fluorophores are covalently attached to diblock copolymers, a number of their physicochemical characteristics can be investigated. This method becomes particularly useful for visualizing phase separation within polymer assemblies and assessing the dynamics of wormlike micelles in real time. Near-IR fluorophores can be covalently conjugated to polymers and this opens the possibility for deep-tissue fluorescence imaging of polymer assemblies in drug delivery applications. |
| format | Article |
| id | doaj-art-a4d00447fbb84ddf88dcd24a661cc9de |
| institution | OA Journals |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-a4d00447fbb84ddf88dcd24a661cc9de2025-08-20T02:23:05ZengWileyInternational Journal of Polymer Science1687-94221687-94302010-01-01201010.1155/2010/379286379286Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer AmphiphilesKarthikan Rajagopal0David A. Christian1Takamasa Harada2Aiwei Tian3Dennis E. Discher4Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USAWormlike micelles and vesicles prepared from diblock copolymers are attracting great interest for a number of technological applications. Although transmission electron microscopy has remained as the method of choice for assessing the morphologies, fluorescence microscopy has a number of advantages. We show here that when commercially available fluorophores are covalently attached to diblock copolymers, a number of their physicochemical characteristics can be investigated. This method becomes particularly useful for visualizing phase separation within polymer assemblies and assessing the dynamics of wormlike micelles in real time. Near-IR fluorophores can be covalently conjugated to polymers and this opens the possibility for deep-tissue fluorescence imaging of polymer assemblies in drug delivery applications.http://dx.doi.org/10.1155/2010/379286 |
| spellingShingle | Karthikan Rajagopal David A. Christian Takamasa Harada Aiwei Tian Dennis E. Discher Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer Amphiphiles International Journal of Polymer Science |
| title | Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer Amphiphiles |
| title_full | Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer Amphiphiles |
| title_fullStr | Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer Amphiphiles |
| title_full_unstemmed | Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer Amphiphiles |
| title_short | Polymersomes and Wormlike Micelles Made Fluorescent by Direct Modifications of Block Copolymer Amphiphiles |
| title_sort | polymersomes and wormlike micelles made fluorescent by direct modifications of block copolymer amphiphiles |
| url | http://dx.doi.org/10.1155/2010/379286 |
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