Pituitary adenylate cyclase-activating polypeptide mediates bacterial endotoxin-induced fever via an effect on cyclooxygenase-2 and inflammatory cytokines

Pituitary adenylate cyclase-activating polypeptide mediates bacterial endotoxin-induced fever via an effect on cyclooxygenase-2 and inflammatory cytokines

Abstract A role for pituitary adenylate cyclase-activating polypeptide (PACAP) signaling was suggested in bacterial lipopolysaccharide (LPS)-induced fever, but the underlying mechanisms of how PACAP contributes to the febrile response have remained unclarified. We administered LPS (120 µg/kg, intrap...

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Bibliographic Details
Main Authors: Jason Sparks, Nora Furedi, Kata Fekete, Margit Solymar, Krisztina Pohoczky, Agnes Kemeny, Dora Reglodi, Andras Garami, Eszter Pakai
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
PACAP
Thermoregulation
Fever
LPS
COX-2
Systemic inflammation
Online Access:https://doi.org/10.1038/s41598-025-08352-0
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