Targeting astrocytes polarization after spinal cord injury: a promising direction
Spinal cord injury (SCI) is a serious neurological injury that causes severe trauma to motor and sensory functions. Although long considered incurable, recent research has brought new hope for functional recovery from SCI. After SCI, astrocytes are activated into many polarization states. Here we di...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1478741/full |
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| author | Helin Li Ying Liu Yucao Sun Hangyu Guo Shiyan Lv Wenhui Guo Jiyu Ren Yufu Wang Jianing Zu Jinglong Yan Nanxiang Wang |
| author_facet | Helin Li Ying Liu Yucao Sun Hangyu Guo Shiyan Lv Wenhui Guo Jiyu Ren Yufu Wang Jianing Zu Jinglong Yan Nanxiang Wang |
| author_sort | Helin Li |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is a serious neurological injury that causes severe trauma to motor and sensory functions. Although long considered incurable, recent research has brought new hope for functional recovery from SCI. After SCI, astrocytes are activated into many polarization states. Here we discuss the two most important classical phenotypes: the ‘A1’ neurotoxic phenotype and the ‘A2’ neuroprotective phenotype, with A1 astrocytes being neurotoxic and impeding neurorecovery, and A2 astrocytes being neuroprotective. This paper discusses the changes in astrocyte responsiveness after SCI and the pros and cons of their polarization in SCI. It also elucidates the feasibility of astrocyte polarization as a therapeutic target for neuroprotection. In the future, multiple intervention strategies targeting astrocyte polarization are expected to gain wider clinical application, ultimately improving motor-sensory function and quality of life in SCI patients. |
| format | Article |
| id | doaj-art-a4c9f69dc4774984b3c5d43245bb5fc3 |
| institution | OA Journals |
| issn | 1662-5102 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-a4c9f69dc4774984b3c5d43245bb5fc32025-08-20T01:47:37ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022024-10-011810.3389/fncel.2024.14787411478741Targeting astrocytes polarization after spinal cord injury: a promising directionHelin Li0Ying Liu1Yucao Sun2Hangyu Guo3Shiyan Lv4Wenhui Guo5Jiyu Ren6Yufu Wang7Jianing Zu8Jinglong Yan9Nanxiang Wang10Department of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, ChinaSpinal cord injury (SCI) is a serious neurological injury that causes severe trauma to motor and sensory functions. Although long considered incurable, recent research has brought new hope for functional recovery from SCI. After SCI, astrocytes are activated into many polarization states. Here we discuss the two most important classical phenotypes: the ‘A1’ neurotoxic phenotype and the ‘A2’ neuroprotective phenotype, with A1 astrocytes being neurotoxic and impeding neurorecovery, and A2 astrocytes being neuroprotective. This paper discusses the changes in astrocyte responsiveness after SCI and the pros and cons of their polarization in SCI. It also elucidates the feasibility of astrocyte polarization as a therapeutic target for neuroprotection. In the future, multiple intervention strategies targeting astrocyte polarization are expected to gain wider clinical application, ultimately improving motor-sensory function and quality of life in SCI patients.https://www.frontiersin.org/articles/10.3389/fncel.2024.1478741/fullSCIastrocyteA1 astrocytesA2 astrocytespolarization |
| spellingShingle | Helin Li Ying Liu Yucao Sun Hangyu Guo Shiyan Lv Wenhui Guo Jiyu Ren Yufu Wang Jianing Zu Jinglong Yan Nanxiang Wang Targeting astrocytes polarization after spinal cord injury: a promising direction Frontiers in Cellular Neuroscience SCI astrocyte A1 astrocytes A2 astrocytes polarization |
| title | Targeting astrocytes polarization after spinal cord injury: a promising direction |
| title_full | Targeting astrocytes polarization after spinal cord injury: a promising direction |
| title_fullStr | Targeting astrocytes polarization after spinal cord injury: a promising direction |
| title_full_unstemmed | Targeting astrocytes polarization after spinal cord injury: a promising direction |
| title_short | Targeting astrocytes polarization after spinal cord injury: a promising direction |
| title_sort | targeting astrocytes polarization after spinal cord injury a promising direction |
| topic | SCI astrocyte A1 astrocytes A2 astrocytes polarization |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1478741/full |
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