Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis
Noninvasive diagnosis of human diseases relies on the detection of molecular markers (probes) in a painless manner. Although extrinsic and intrinsic molecular markers are often used, intrinsic disease probes (molecular markers) are preferable because they are naturally present in our body, and devia...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2024.1463273/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850149802870833152 |
|---|---|
| author | Lopamudra Roy Shweta Paul Amrita Banerjee Ria Ghosh Susmita Mondal Monojit Das Monojit Das Nivedita Pan Ishitri Das Soumendra Singh Debasish Bhattacharya Asim Kumar Mallick Samir Kumar Pal |
| author_facet | Lopamudra Roy Shweta Paul Amrita Banerjee Ria Ghosh Susmita Mondal Monojit Das Monojit Das Nivedita Pan Ishitri Das Soumendra Singh Debasish Bhattacharya Asim Kumar Mallick Samir Kumar Pal |
| author_sort | Lopamudra Roy |
| collection | DOAJ |
| description | Noninvasive diagnosis of human diseases relies on the detection of molecular markers (probes) in a painless manner. Although extrinsic and intrinsic molecular markers are often used, intrinsic disease probes (molecular markers) are preferable because they are naturally present in our body, and deviation in their concentration from normal levels clearly indicates anomalies in human bodies, that is, diseases. In this study, we report noninvasive spectroscopic measurements of total haemoglobin (Hb), bilirubin, and the ratio of oxy- and deoxyhaemoglobin as disease markers for anaemia, jaundice, and oxygen deficiency, respectively, using a meticulously designed optical fibre probe. The challenges in designing the fibre probe for simultaneous noninvasive detection, including optical power, spectral density of the probing light, and resolution of the spectrometer, were found to be critical to accurate measurements. Finally, a fibre-less, highly portable, and low-cost prototype was developed and tested in human clinical trials for the diagnosis of diseases, and these results were compared with conventional techniques (blood tests). |
| format | Article |
| id | doaj-art-a4c85f231ff345c5a4df467ad834bced |
| institution | OA Journals |
| issn | 2296-2646 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj-art-a4c85f231ff345c5a4df467ad834bced2025-08-20T02:26:46ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462025-01-011210.3389/fchem.2024.14632731463273Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosisLopamudra Roy0Shweta Paul1Amrita Banerjee2Ria Ghosh3Susmita Mondal4Monojit Das5Monojit Das6Nivedita Pan7Ishitri Das8Soumendra Singh9Debasish Bhattacharya10Asim Kumar Mallick11Samir Kumar Pal12Department of Applied Optics and Photonics, University of Calcutta, Kolkata, IndiaDepartment of Paediatric Medicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, IndiaDepartment of Physics, Jadavpur University, Kolkata, IndiaDepartment of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata, IndiaDepartment of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata, IndiaDepartment of Zoology, Vidyasagar University, Midnapore, IndiaDepartment of Zoology, Uluberia College, University of Calcutta, Howrah, IndiaDepartment of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata, IndiaDepartment of Paediatric Medicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, IndiaDepartment of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata, IndiaDepartment of Gynecology and Obstetrics, Nil Ratan Sircar Medical College and Hospital, Kolkata, IndiaDepartment of Paediatric Medicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, IndiaDepartment of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata, IndiaNoninvasive diagnosis of human diseases relies on the detection of molecular markers (probes) in a painless manner. Although extrinsic and intrinsic molecular markers are often used, intrinsic disease probes (molecular markers) are preferable because they are naturally present in our body, and deviation in their concentration from normal levels clearly indicates anomalies in human bodies, that is, diseases. In this study, we report noninvasive spectroscopic measurements of total haemoglobin (Hb), bilirubin, and the ratio of oxy- and deoxyhaemoglobin as disease markers for anaemia, jaundice, and oxygen deficiency, respectively, using a meticulously designed optical fibre probe. The challenges in designing the fibre probe for simultaneous noninvasive detection, including optical power, spectral density of the probing light, and resolution of the spectrometer, were found to be critical to accurate measurements. Finally, a fibre-less, highly portable, and low-cost prototype was developed and tested in human clinical trials for the diagnosis of diseases, and these results were compared with conventional techniques (blood tests).https://www.frontiersin.org/articles/10.3389/fchem.2024.1463273/fullnoninvasivehaemoglobinbilirubinoxygen saturationportablelow cost |
| spellingShingle | Lopamudra Roy Shweta Paul Amrita Banerjee Ria Ghosh Susmita Mondal Monojit Das Monojit Das Nivedita Pan Ishitri Das Soumendra Singh Debasish Bhattacharya Asim Kumar Mallick Samir Kumar Pal Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis Frontiers in Chemistry noninvasive haemoglobin bilirubin oxygen saturation portable low cost |
| title | Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis |
| title_full | Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis |
| title_fullStr | Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis |
| title_full_unstemmed | Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis |
| title_short | Challenges in “probing spectroscopic probes” for noninvasive simultaneous disease diagnosis |
| title_sort | challenges in probing spectroscopic probes for noninvasive simultaneous disease diagnosis |
| topic | noninvasive haemoglobin bilirubin oxygen saturation portable low cost |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1463273/full |
| work_keys_str_mv | AT lopamudraroy challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT shwetapaul challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT amritabanerjee challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT riaghosh challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT susmitamondal challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT monojitdas challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT monojitdas challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT niveditapan challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT ishitridas challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT soumendrasingh challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT debasishbhattacharya challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT asimkumarmallick challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis AT samirkumarpal challengesinprobingspectroscopicprobesfornoninvasivesimultaneousdiseasediagnosis |