Design and immunogenic evaluation of multi-epitope vaccines for colorectal cancer: insights from molecular dynamics and In-Vitro studies

Design and immunogenic evaluation of multi-epitope vaccines for colorectal cancer: insights from molecular dynamics and In-Vitro studies

BackgroundThis study aimed to identify cytotoxic T lymphocyte (CTL)-specific epitopes from three tumor-associated antigens (TAAs)—Dickkopf-like 1 (DKKL1), F-box protein 39 (FBXO39), and Opa-interacting protein 5 (OIP5)—which are overexpressed in colorectal cancer (CRC), as potential candidates for C...

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Bibliographic Details
Main Authors: Peiwei Sun, Luolin Wang, Zhong Liu, Zhenglei Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
cytotoxic T lymphocyte
Dickkopf-like 1 protein
F-box protein 39
Opa-interacting protein 5
Toll-Like Receptor 4
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1592072/full
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