RNF13 mediates pH- and Ca2+-dependent regulation of lysosomal positioning

RNF13 mediates pH- and Ca2+-dependent regulation of lysosomal positioning

Summary: Environmental factors such as extracellular pH (pHe) and nutrition status affect lysosomal localization and autophagy, but how pHe, intracellular pH (pHi), and Ca2+ regulate lysosome transport is not well understood. Here, we identify RNF13 as a key regulator of lysosomal positioning via pH...

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Main Authors: Lan Thi Trinh, Anh Van Vu, Seunghye Shin, Chanhaeng Lee, Sang-Hee Park, Eun-Bee Cho, Yunseok Heo, Hyun Jin Kim, Sungjoo Kim, Jong-Bok Yoon
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008241
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