Serine metabolism in tumor progression and immunotherapy
Abstract Serine plays a vital role in various metabolic processes including the synthesis of proteins and other amino acids, which are essential for the cell proliferation and growth. Cancer cells either absorb exogenous serine or produce it through the serine synthesis pathway, enabling the generat...
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| Format: | Article |
| Language: | English |
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Springer
2025-04-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02358-w |
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| author | Dong Huang Hui Cai HaiYu Huang |
| author_facet | Dong Huang Hui Cai HaiYu Huang |
| author_sort | Dong Huang |
| collection | DOAJ |
| description | Abstract Serine plays a vital role in various metabolic processes including the synthesis of proteins and other amino acids, which are essential for the cell proliferation and growth. Cancer cells either absorb exogenous serine or produce it through the serine synthesis pathway, enabling the generation of intracellular glycine and one-carbon units, which are crucial for nucleotide biosynthesis. This metabolic process, referred to as serine-glycine-one-carbon (SGOC) metabolism, is essential for tumorigenesis and exhibits considerable complexity and clinical significance. Enzymes involved in the SGOC pathway are linked to tumor growth, metastasis, and resistance to therapies. The SGOC pathway is a vital metabolic network that facilitates cell survival and proliferation, especially in aggressive cancers. Understanding how this network is regulated is crucial for tackling tumor heterogeneity and recurrence. This review emphasizes recent advancements in understanding the roles and effects of the SGOC metabolic pathway in the context of cancer progression. Additionally, it outlines the complex influences of the SGOC metabolic pathway on the tumor microenvironment (TME), offering potential strategies to enhance cancer immunotherapy. |
| format | Article |
| id | doaj-art-a4bf3a59976b44d084259b93ac1c11c2 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-a4bf3a59976b44d084259b93ac1c11c22025-08-20T02:55:35ZengSpringerDiscover Oncology2730-60112025-04-0116111910.1007/s12672-025-02358-wSerine metabolism in tumor progression and immunotherapyDong Huang0Hui Cai1HaiYu Huang2Oncology Hematology Department, Fengdu General HospitalOncology Hematology Department, Fengdu General HospitalOncology Hematology Department, Fengdu General HospitalAbstract Serine plays a vital role in various metabolic processes including the synthesis of proteins and other amino acids, which are essential for the cell proliferation and growth. Cancer cells either absorb exogenous serine or produce it through the serine synthesis pathway, enabling the generation of intracellular glycine and one-carbon units, which are crucial for nucleotide biosynthesis. This metabolic process, referred to as serine-glycine-one-carbon (SGOC) metabolism, is essential for tumorigenesis and exhibits considerable complexity and clinical significance. Enzymes involved in the SGOC pathway are linked to tumor growth, metastasis, and resistance to therapies. The SGOC pathway is a vital metabolic network that facilitates cell survival and proliferation, especially in aggressive cancers. Understanding how this network is regulated is crucial for tackling tumor heterogeneity and recurrence. This review emphasizes recent advancements in understanding the roles and effects of the SGOC metabolic pathway in the context of cancer progression. Additionally, it outlines the complex influences of the SGOC metabolic pathway on the tumor microenvironment (TME), offering potential strategies to enhance cancer immunotherapy.https://doi.org/10.1007/s12672-025-02358-wSerineOne-carbon metabolismTumor progressionTumor microenvironmentImmunotherapy |
| spellingShingle | Dong Huang Hui Cai HaiYu Huang Serine metabolism in tumor progression and immunotherapy Discover Oncology Serine One-carbon metabolism Tumor progression Tumor microenvironment Immunotherapy |
| title | Serine metabolism in tumor progression and immunotherapy |
| title_full | Serine metabolism in tumor progression and immunotherapy |
| title_fullStr | Serine metabolism in tumor progression and immunotherapy |
| title_full_unstemmed | Serine metabolism in tumor progression and immunotherapy |
| title_short | Serine metabolism in tumor progression and immunotherapy |
| title_sort | serine metabolism in tumor progression and immunotherapy |
| topic | Serine One-carbon metabolism Tumor progression Tumor microenvironment Immunotherapy |
| url | https://doi.org/10.1007/s12672-025-02358-w |
| work_keys_str_mv | AT donghuang serinemetabolismintumorprogressionandimmunotherapy AT huicai serinemetabolismintumorprogressionandimmunotherapy AT haiyuhuang serinemetabolismintumorprogressionandimmunotherapy |