Recent Advances in Aggregation-Induced Emission (AIE) Fluorescent Sensors for Biomolecule Detection
Fluorescent sensors are indispensable tools in fields such as molecular biology, clinical diagnostics, biotechnology, and environmental monitoring, due to their high sensitivity, selectivity, biocompatibility, rapid response, and ease of use. However, conventional fluorophores often suffer from aggr...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
|
| Series: | Chemosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9040/13/5/174 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850257103483043840 |
|---|---|
| author | Kavya S. Keremane M. Gururaj Acharya Praveen Naik Chandi C. Malakar Kai Wang Bed Poudel |
| author_facet | Kavya S. Keremane M. Gururaj Acharya Praveen Naik Chandi C. Malakar Kai Wang Bed Poudel |
| author_sort | Kavya S. Keremane |
| collection | DOAJ |
| description | Fluorescent sensors are indispensable tools in fields such as molecular biology, clinical diagnostics, biotechnology, and environmental monitoring, due to their high sensitivity, selectivity, biocompatibility, rapid response, and ease of use. However, conventional fluorophores often suffer from aggregation-caused quenching (ACQ), leading to diminished fluorescence in the aggregated state. The advent of aggregation-induced emission (AIE) luminogens, which exhibit enhanced fluorescence upon aggregation, offers a powerful solution to this limitation. Their unique photophysical properties have made AIE-based materials highly valuable for diverse applications, including biomedical imaging, optoelectronics, stimuli-responsive systems, drug delivery, and chemical sensing. Notably, AIE-based fluorescent probes are emerging as attractive alternatives to traditional analytical methods owing to their low cost, fast detection, and high selectivity. Over the past two decades, considerable progress has been made in the rational design and development of AIE-active small-molecule fluorescent probes for detecting a wide variety of analytes, such as biologically relevant molecules, drug compounds, volatile organic compounds (VOCs), explosives, and contaminants associated with forensic and food safety analysis. This review highlights recent advances in organic AIE-based fluorescent probes, beginning with the fundamentals of AIE and typical “turn-on” sensing mechanisms, and concluding with a discussion of current challenges and future opportunities in this rapidly evolving research area. |
| format | Article |
| id | doaj-art-a4bd7cb024a14d9eb23e0f9483580102 |
| institution | OA Journals |
| issn | 2227-9040 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj-art-a4bd7cb024a14d9eb23e0f94835801022025-08-20T01:56:29ZengMDPI AGChemosensors2227-90402025-05-0113517410.3390/chemosensors13050174Recent Advances in Aggregation-Induced Emission (AIE) Fluorescent Sensors for Biomolecule DetectionKavya S. Keremane0M. Gururaj Acharya1Praveen Naik2Chandi C. Malakar3Kai Wang4Bed Poudel5Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USASchool of Sustainable Engineering and the Built Environment, Arizona State University, Tempe, AZ 85287, USADepartment of Chemistry, Nitte Meenakshi Institute of Technology, Yelahanka, Bengaluru 560064, Karnataka, IndiaDepartment of Chemistry, National Institute of Technology Manipur, Imphal 795004, Manipur, IndiaDepartment of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USADepartment of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USAFluorescent sensors are indispensable tools in fields such as molecular biology, clinical diagnostics, biotechnology, and environmental monitoring, due to their high sensitivity, selectivity, biocompatibility, rapid response, and ease of use. However, conventional fluorophores often suffer from aggregation-caused quenching (ACQ), leading to diminished fluorescence in the aggregated state. The advent of aggregation-induced emission (AIE) luminogens, which exhibit enhanced fluorescence upon aggregation, offers a powerful solution to this limitation. Their unique photophysical properties have made AIE-based materials highly valuable for diverse applications, including biomedical imaging, optoelectronics, stimuli-responsive systems, drug delivery, and chemical sensing. Notably, AIE-based fluorescent probes are emerging as attractive alternatives to traditional analytical methods owing to their low cost, fast detection, and high selectivity. Over the past two decades, considerable progress has been made in the rational design and development of AIE-active small-molecule fluorescent probes for detecting a wide variety of analytes, such as biologically relevant molecules, drug compounds, volatile organic compounds (VOCs), explosives, and contaminants associated with forensic and food safety analysis. This review highlights recent advances in organic AIE-based fluorescent probes, beginning with the fundamentals of AIE and typical “turn-on” sensing mechanisms, and concluding with a discussion of current challenges and future opportunities in this rapidly evolving research area.https://www.mdpi.com/2227-9040/13/5/174fluorescent sensorAIEfluorescencebiomolecule detection |
| spellingShingle | Kavya S. Keremane M. Gururaj Acharya Praveen Naik Chandi C. Malakar Kai Wang Bed Poudel Recent Advances in Aggregation-Induced Emission (AIE) Fluorescent Sensors for Biomolecule Detection Chemosensors fluorescent sensor AIE fluorescence biomolecule detection |
| title | Recent Advances in Aggregation-Induced Emission (AIE) Fluorescent Sensors for Biomolecule Detection |
| title_full | Recent Advances in Aggregation-Induced Emission (AIE) Fluorescent Sensors for Biomolecule Detection |
| title_fullStr | Recent Advances in Aggregation-Induced Emission (AIE) Fluorescent Sensors for Biomolecule Detection |
| title_full_unstemmed | Recent Advances in Aggregation-Induced Emission (AIE) Fluorescent Sensors for Biomolecule Detection |
| title_short | Recent Advances in Aggregation-Induced Emission (AIE) Fluorescent Sensors for Biomolecule Detection |
| title_sort | recent advances in aggregation induced emission aie fluorescent sensors for biomolecule detection |
| topic | fluorescent sensor AIE fluorescence biomolecule detection |
| url | https://www.mdpi.com/2227-9040/13/5/174 |
| work_keys_str_mv | AT kavyaskeremane recentadvancesinaggregationinducedemissionaiefluorescentsensorsforbiomoleculedetection AT mgururajacharya recentadvancesinaggregationinducedemissionaiefluorescentsensorsforbiomoleculedetection AT praveennaik recentadvancesinaggregationinducedemissionaiefluorescentsensorsforbiomoleculedetection AT chandicmalakar recentadvancesinaggregationinducedemissionaiefluorescentsensorsforbiomoleculedetection AT kaiwang recentadvancesinaggregationinducedemissionaiefluorescentsensorsforbiomoleculedetection AT bedpoudel recentadvancesinaggregationinducedemissionaiefluorescentsensorsforbiomoleculedetection |