CCR7+ dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse

CCR7+ dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse

Abstract Interleukin (IL)−23 is the master pathogenic cytokine in psoriasis and neutralization of IL-23 alleviates psoriasis. Psoriasis relapses after the withdrawal of anti-IL-23 antibodies, and the persistence of IL-23-producing cells potentially contributes to such recurrence, but the cellular so...

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Main Authors: Yang Sun, Fangzhou Lou, Xiaojie Cai, Zhikai Wang, Xiuli Yang, Libo Sun, Zhenyao Xu, Siyu Deng, Zhouwei Wu, Zhaoyuan Liu, Yu-Ling Shi, Florent Ginhoux, Honglin Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62874-9
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