Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage
The intestinal barrier plays a key role in preventing harmful substance invasions and maintaining intestinal homeostasis, with tight junction proteins being essential for maintaining the integrity of the intestinal barrier. This review summarizes the structural composition of the intestinal barrier,...
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| Format: | Article |
| Language: | English |
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China Food Publishing Company
2024-12-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-24-032.pdf |
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| author | LI Yu, OUYANG Fangxin, ZHANG He, WANG Wenyu, DONG Jingxiao, LI Dapeng, LI Feng |
| author_facet | LI Yu, OUYANG Fangxin, ZHANG He, WANG Wenyu, DONG Jingxiao, LI Dapeng, LI Feng |
| author_sort | LI Yu, OUYANG Fangxin, ZHANG He, WANG Wenyu, DONG Jingxiao, LI Dapeng, LI Feng |
| collection | DOAJ |
| description | The intestinal barrier plays a key role in preventing harmful substance invasions and maintaining intestinal homeostasis, with tight junction proteins being essential for maintaining the integrity of the intestinal barrier. This review summarizes the structural composition of the intestinal barrier, the role of tight junction in maintaining intestinal physiological functions, with an emphasis on the potential application value of the major phenolic components in ginger, 6-gingerol and 6-shogaol, for alleviating tight junction damage. Through comprehensive analysis of clinical research and experimental results in recent years, it is found that 6-gingerol and 6-shogaol can improve the expression levels of tight junction-related proteins and maintain the integrity and biofunction of the intestinal barrier by inhibiting inflammation, oxidative stress and apoptosis as well as regulating the composition of intestinal microbiota. This paper provides a theoretical basis and insights for understanding the mechanisms of action of ginger phenolic compounds in regulating health and for expanding their application scopes. |
| format | Article |
| id | doaj-art-a4b899bbd3cc4cbab208c3869f6fac21 |
| institution | Kabale University |
| issn | 1002-6630 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj-art-a4b899bbd3cc4cbab208c3869f6fac212025-02-05T09:08:01ZengChina Food Publishing CompanyShipin Kexue1002-66302024-12-01452428229210.7506/spkx1002-6630-20240507-026Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction DamageLI Yu, OUYANG Fangxin, ZHANG He, WANG Wenyu, DONG Jingxiao, LI Dapeng, LI Feng0(Key Laboratory of Food Nutrition and Health in Universities of Shandong, College of Food Science and Engineering, Shandong Agricultural University, Tai’an 271018, China)The intestinal barrier plays a key role in preventing harmful substance invasions and maintaining intestinal homeostasis, with tight junction proteins being essential for maintaining the integrity of the intestinal barrier. This review summarizes the structural composition of the intestinal barrier, the role of tight junction in maintaining intestinal physiological functions, with an emphasis on the potential application value of the major phenolic components in ginger, 6-gingerol and 6-shogaol, for alleviating tight junction damage. Through comprehensive analysis of clinical research and experimental results in recent years, it is found that 6-gingerol and 6-shogaol can improve the expression levels of tight junction-related proteins and maintain the integrity and biofunction of the intestinal barrier by inhibiting inflammation, oxidative stress and apoptosis as well as regulating the composition of intestinal microbiota. This paper provides a theoretical basis and insights for understanding the mechanisms of action of ginger phenolic compounds in regulating health and for expanding their application scopes.https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-24-032.pdf6-gingerol; 6-shogaol; tight junction; intestinal barrier; intestinal injury |
| spellingShingle | LI Yu, OUYANG Fangxin, ZHANG He, WANG Wenyu, DONG Jingxiao, LI Dapeng, LI Feng Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage Shipin Kexue 6-gingerol; 6-shogaol; tight junction; intestinal barrier; intestinal injury |
| title | Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage |
| title_full | Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage |
| title_fullStr | Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage |
| title_full_unstemmed | Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage |
| title_short | Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage |
| title_sort | research progress on alleviatory effects of 6 gingerol and 6 shogaol on intestine tight junction damage |
| topic | 6-gingerol; 6-shogaol; tight junction; intestinal barrier; intestinal injury |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2024-45-24-032.pdf |
| work_keys_str_mv | AT liyuouyangfangxinzhanghewangwenyudongjingxiaolidapenglifeng researchprogressonalleviatoryeffectsof6gingeroland6shogaolonintestinetightjunctiondamage |