Impact of Continuous Glucose Monitoring on Hemoglobin A1c and Height Trends in Latin American Children with Type 1 Diabetes Onset over 3 Years: A Multicenter Study

Objective: To evaluate changes in hemoglobin A1c (HbA1c) levels and z-height over 3 years based on continuous glucose monitoring (CGM) usage among children with new-onset type 1 diabetes (T1DM) from various Latin American centers. Study design: Data on z-height, CGM access, and HbA1c (%) were collec...

Full description

Saved in:
Bibliographic Details
Main Authors: Valeria Hirschler, MD, Claudia Molinari, Msc, Claudio D. Gonzalez, MD, Maria Eugenia Andres, Angela Figueroa Sobrero, Victoria Femenia, Guadalupe Pietropaolo, Maria L. Major, Edit Scaiola, Sandra Mazzetti, Patricia Pasayo, Amanda J. Benitez, Andrea Escalante Marassi, Laura Pardo, Julie Pelicand, Carlos M. Del Aguila Villar, Alejandra Franchello, Ernesto Bogado, Julieta Pomilio, Rosa Flores, Elizabeth Garcia Rusca, Andrea Soledad Reinoso, Analia Morin, Eduardo Rossi, Veronica Vacarezza, Daniela Rodríguez Fuentes, Paula Paz Povedano, Ana L. Garcia, Teresa Martinez, Fabiola Blanco, Oswaldo Núñez Almache, Ana Parada, Patricia Bocco, M Laura Arzamendia, Carla Mannucci, Patricia Taberner, Laura Braguinsky
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Pediatrics: Clinical Practice
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S295054102400036X
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1850109316483252224
author Valeria Hirschler, MD
Claudia Molinari, Msc
Claudio D. Gonzalez, MD
Maria Eugenia Andres
Angela Figueroa Sobrero
Victoria Femenia
Guadalupe Pietropaolo
Maria L. Major
Edit Scaiola
Sandra Mazzetti
Patricia Pasayo
Amanda J. Benitez
Andrea Escalante Marassi
Laura Pardo
Julie Pelicand
Carlos M. Del Aguila Villar
Alejandra Franchello
Ernesto Bogado
Julieta Pomilio
Rosa Flores
Elizabeth Garcia Rusca
Andrea Soledad Reinoso
Analia Morin
Eduardo Rossi
Veronica Vacarezza
Daniela Rodríguez Fuentes
Paula Paz Povedano
Ana L. Garcia
Teresa Martinez
Fabiola Blanco
Oswaldo Núñez Almache
Ana Parada
Patricia Bocco
M Laura Arzamendia
Carla Mannucci
Patricia Taberner
Laura Braguinsky
author_facet Valeria Hirschler, MD
Claudia Molinari, Msc
Claudio D. Gonzalez, MD
Maria Eugenia Andres
Angela Figueroa Sobrero
Victoria Femenia
Guadalupe Pietropaolo
Maria L. Major
Edit Scaiola
Sandra Mazzetti
Patricia Pasayo
Amanda J. Benitez
Andrea Escalante Marassi
Laura Pardo
Julie Pelicand
Carlos M. Del Aguila Villar
Alejandra Franchello
Ernesto Bogado
Julieta Pomilio
Rosa Flores
Elizabeth Garcia Rusca
Andrea Soledad Reinoso
Analia Morin
Eduardo Rossi
Veronica Vacarezza
Daniela Rodríguez Fuentes
Paula Paz Povedano
Ana L. Garcia
Teresa Martinez
Fabiola Blanco
Oswaldo Núñez Almache
Ana Parada
Patricia Bocco
M Laura Arzamendia
Carla Mannucci
Patricia Taberner
Laura Braguinsky
author_sort Valeria Hirschler, MD
collection DOAJ
description Objective: To evaluate changes in hemoglobin A1c (HbA1c) levels and z-height over 3 years based on continuous glucose monitoring (CGM) usage among children with new-onset type 1 diabetes (T1DM) from various Latin American centers. Study design: Data on z-height, CGM access, and HbA1c (%) were collected for Latin American children aged 6 months to 18 years with T1DM onset from 19 centers in a retrospective analysis of medical records, from 2020 to 2023. A 2-way ANOVA method with repeated measures and multiple regression analyses were performed. Results: We included 433 children (46.0% female) aged 8.7 ± 3.7 years; 199 (45.9%) used CGM. The mean HbA1c was significantly lower in years 1, 2, and 3 than at baseline in children with CGM, but not those without CGM. The z-height decreased significantly with the years in both groups. However, the CGM users showed a significantly greater height in years 2 and 3 than the nonusers. Multiple linear regression analysis showed that CGM users exhibited a significantly lower incremental area under the curve (AUC) for HbA1c during follow-up than nonusers. Furthermore, a lower incremental AUC for HbA1c was associated with a smaller decremental AUC for z-height (R2 = 0.19). Multiple logistic regression analysis revealed that children with CGM were 80% more likely (OR, 0.22; 95% CI, 0.1-0.6) to achieve an HbA1c of <7% in the third year of follow-up. Conclusions: This study reveals a significant association between CGM use and lower HbA1c from the onset of T1DM over a 3-year follow-up in Latin American children. Further prospective studies should be performed to confirm this finding.
format Article
id doaj-art-a4b641e0c1944de49a4d52d661f4053f
institution OA Journals
issn 2950-5410
language English
publishDate 2024-12-01
publisher Elsevier
record_format Article
series Journal of Pediatrics: Clinical Practice
spelling doaj-art-a4b641e0c1944de49a4d52d661f4053f2025-08-20T02:38:06ZengElsevierJournal of Pediatrics: Clinical Practice2950-54102024-12-011420013010.1016/j.jpedcp.2024.200130Impact of Continuous Glucose Monitoring on Hemoglobin A1c and Height Trends in Latin American Children with Type 1 Diabetes Onset over 3 Years: A Multicenter StudyValeria Hirschler, MD0Claudia Molinari, Msc1Claudio D. Gonzalez, MD2Maria Eugenia AndresAngela Figueroa SobreroVictoria FemeniaGuadalupe PietropaoloMaria L. MajorEdit ScaiolaSandra MazzettiPatricia PasayoAmanda J. BenitezAndrea Escalante MarassiLaura PardoJulie PelicandCarlos M. Del Aguila VillarAlejandra FranchelloErnesto BogadoJulieta PomilioRosa FloresElizabeth Garcia RuscaAndrea Soledad ReinosoAnalia MorinEduardo RossiVeronica VacarezzaDaniela Rodríguez FuentesPaula Paz PovedanoAna L. GarciaTeresa MartinezFabiola BlancoOswaldo Núñez AlmacheAna ParadaPatricia BoccoM Laura ArzamendiaCarla MannucciPatricia TabernerLaura BraguinskyArgentine Diabetes Society, Epidemiology Department, Buenos Aires, Argentina; Reprint requests: Valeria Hirschler, MD, Argentine Diabetes Society, Epidemiology Department, Maipu, 812 5 M, Buenos Aires 1006, Argentina.UBA School of Pharmacy and Biochemistry, Mathematics, Buenos Aires, ArgentinaCEMIC, Pharmacology, Buenos Aires, ArgentinaObjective: To evaluate changes in hemoglobin A1c (HbA1c) levels and z-height over 3 years based on continuous glucose monitoring (CGM) usage among children with new-onset type 1 diabetes (T1DM) from various Latin American centers. Study design: Data on z-height, CGM access, and HbA1c (%) were collected for Latin American children aged 6 months to 18 years with T1DM onset from 19 centers in a retrospective analysis of medical records, from 2020 to 2023. A 2-way ANOVA method with repeated measures and multiple regression analyses were performed. Results: We included 433 children (46.0% female) aged 8.7 ± 3.7 years; 199 (45.9%) used CGM. The mean HbA1c was significantly lower in years 1, 2, and 3 than at baseline in children with CGM, but not those without CGM. The z-height decreased significantly with the years in both groups. However, the CGM users showed a significantly greater height in years 2 and 3 than the nonusers. Multiple linear regression analysis showed that CGM users exhibited a significantly lower incremental area under the curve (AUC) for HbA1c during follow-up than nonusers. Furthermore, a lower incremental AUC for HbA1c was associated with a smaller decremental AUC for z-height (R2 = 0.19). Multiple logistic regression analysis revealed that children with CGM were 80% more likely (OR, 0.22; 95% CI, 0.1-0.6) to achieve an HbA1c of <7% in the third year of follow-up. Conclusions: This study reveals a significant association between CGM use and lower HbA1c from the onset of T1DM over a 3-year follow-up in Latin American children. Further prospective studies should be performed to confirm this finding.http://www.sciencedirect.com/science/article/pii/S295054102400036XLatin American childrentype 1 diabetesheightCGM
spellingShingle Valeria Hirschler, MD
Claudia Molinari, Msc
Claudio D. Gonzalez, MD
Maria Eugenia Andres
Angela Figueroa Sobrero
Victoria Femenia
Guadalupe Pietropaolo
Maria L. Major
Edit Scaiola
Sandra Mazzetti
Patricia Pasayo
Amanda J. Benitez
Andrea Escalante Marassi
Laura Pardo
Julie Pelicand
Carlos M. Del Aguila Villar
Alejandra Franchello
Ernesto Bogado
Julieta Pomilio
Rosa Flores
Elizabeth Garcia Rusca
Andrea Soledad Reinoso
Analia Morin
Eduardo Rossi
Veronica Vacarezza
Daniela Rodríguez Fuentes
Paula Paz Povedano
Ana L. Garcia
Teresa Martinez
Fabiola Blanco
Oswaldo Núñez Almache
Ana Parada
Patricia Bocco
M Laura Arzamendia
Carla Mannucci
Patricia Taberner
Laura Braguinsky
Impact of Continuous Glucose Monitoring on Hemoglobin A1c and Height Trends in Latin American Children with Type 1 Diabetes Onset over 3 Years: A Multicenter Study
Journal of Pediatrics: Clinical Practice
Latin American children
type 1 diabetes
height
CGM
title Impact of Continuous Glucose Monitoring on Hemoglobin A1c and Height Trends in Latin American Children with Type 1 Diabetes Onset over 3 Years: A Multicenter Study
title_full Impact of Continuous Glucose Monitoring on Hemoglobin A1c and Height Trends in Latin American Children with Type 1 Diabetes Onset over 3 Years: A Multicenter Study
title_fullStr Impact of Continuous Glucose Monitoring on Hemoglobin A1c and Height Trends in Latin American Children with Type 1 Diabetes Onset over 3 Years: A Multicenter Study
title_full_unstemmed Impact of Continuous Glucose Monitoring on Hemoglobin A1c and Height Trends in Latin American Children with Type 1 Diabetes Onset over 3 Years: A Multicenter Study
title_short Impact of Continuous Glucose Monitoring on Hemoglobin A1c and Height Trends in Latin American Children with Type 1 Diabetes Onset over 3 Years: A Multicenter Study
title_sort impact of continuous glucose monitoring on hemoglobin a1c and height trends in latin american children with type 1 diabetes onset over 3 years a multicenter study
topic Latin American children
type 1 diabetes
height
CGM
url http://www.sciencedirect.com/science/article/pii/S295054102400036X
work_keys_str_mv AT valeriahirschlermd impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT claudiamolinarimsc impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT claudiodgonzalezmd impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT mariaeugeniaandres impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT angelafigueroasobrero impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT victoriafemenia impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT guadalupepietropaolo impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT marialmajor impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT editscaiola impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT sandramazzetti impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT patriciapasayo impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT amandajbenitez impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT andreaescalantemarassi impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT laurapardo impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT juliepelicand impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT carlosmdelaguilavillar impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT alejandrafranchello impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT ernestobogado impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT julietapomilio impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT rosaflores impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT elizabethgarciarusca impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT andreasoledadreinoso impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT analiamorin impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT eduardorossi impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT veronicavacarezza impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT danielarodriguezfuentes impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT paulapazpovedano impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT analgarcia impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT teresamartinez impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT fabiolablanco impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT oswaldonunezalmache impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT anaparada impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT patriciabocco impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT mlauraarzamendia impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT carlamannucci impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT patriciataberner impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy
AT laurabraguinsky impactofcontinuousglucosemonitoringonhemoglobina1candheighttrendsinlatinamericanchildrenwithtype1diabetesonsetover3yearsamulticenterstudy