Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Oncogene‐induced replication stress (RS) is a vulnerability of cancer cells that forces reliance on the intra‐S‐phase checkpoint to ensure faithful genome duplication. Inhibitors of the intra‐S‐phase checkpoint kinases ATR and CHK1 have been developed, but resistance to these drugs remains problemat...

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Bibliographic Details
Main Authors: Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. vanLiere, Bart Westendorp
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Molecular Oncology
Subjects:
CHK1
FOXM1
gemcitabine
oncogenic RAS
replication stress
single‐cell RNA‐sequencing
Online Access:https://doi.org/10.1002/1878-0261.13819
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