Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based Process
An original technique, based on supercritical CO2 and on the particles from gas saturated solution (PGSS) micronization method, was developed to obtain magnetically active lipid microparticles. Magnetite nanoparticles (MNPs) were encapsulated into triestearin and phosphatidylcholine mixtures to incr...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Chemical Engineering |
| Online Access: | http://dx.doi.org/10.1155/2009/781247 |
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| author | Keti Vezzù Chiara Campolmi Alberto Bertucco |
| author_facet | Keti Vezzù Chiara Campolmi Alberto Bertucco |
| author_sort | Keti Vezzù |
| collection | DOAJ |
| description | An original technique, based on supercritical CO2 and on the particles from gas saturated solution (PGSS) micronization method, was developed to obtain magnetically active lipid microparticles. Magnetite nanoparticles (MNPs) were encapsulated into triestearin and phosphatidylcholine mixtures to increase their biocompatibility for future applications in the fields of biomedical diagnostics and therapeutic medications. The lipid particles produced were characterized to determine size and size distribution, and to confirm the encapsulation of MNP. The mean size was in the range of 200–800 nm. The possibility to drive these magnetically active particles by an external magnet was demonstrated in a simple apparatus simulating a vessel of the circulatory system. The results obtained indicate that the modified PGSS technique is suitable to produce lipid microparticles with magnetic activity for possible use in medical applications. |
| format | Article |
| id | doaj-art-a4afe866b34048deaac1fb08ec387bf0 |
| institution | Kabale University |
| issn | 1687-806X 1687-8078 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Chemical Engineering |
| spelling | doaj-art-a4afe866b34048deaac1fb08ec387bf02025-02-03T01:00:34ZengWileyInternational Journal of Chemical Engineering1687-806X1687-80782009-01-01200910.1155/2009/781247781247Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based ProcessKeti Vezzù0Chiara Campolmi1Alberto Bertucco2DIPIC—Dipartimento di Principi e Impianti di Ingegneria Chimica, via Marzolo, 9, I-35131 Padova, ItalyDIPIC—Dipartimento di Principi e Impianti di Ingegneria Chimica, via Marzolo, 9, I-35131 Padova, ItalyDIPIC—Dipartimento di Principi e Impianti di Ingegneria Chimica, via Marzolo, 9, I-35131 Padova, ItalyAn original technique, based on supercritical CO2 and on the particles from gas saturated solution (PGSS) micronization method, was developed to obtain magnetically active lipid microparticles. Magnetite nanoparticles (MNPs) were encapsulated into triestearin and phosphatidylcholine mixtures to increase their biocompatibility for future applications in the fields of biomedical diagnostics and therapeutic medications. The lipid particles produced were characterized to determine size and size distribution, and to confirm the encapsulation of MNP. The mean size was in the range of 200–800 nm. The possibility to drive these magnetically active particles by an external magnet was demonstrated in a simple apparatus simulating a vessel of the circulatory system. The results obtained indicate that the modified PGSS technique is suitable to produce lipid microparticles with magnetic activity for possible use in medical applications.http://dx.doi.org/10.1155/2009/781247 |
| spellingShingle | Keti Vezzù Chiara Campolmi Alberto Bertucco Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based Process International Journal of Chemical Engineering |
| title | Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based Process |
| title_full | Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based Process |
| title_fullStr | Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based Process |
| title_full_unstemmed | Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based Process |
| title_short | Production of Lipid Microparticles Magnetically Active by a Supercritical Fluid-Based Process |
| title_sort | production of lipid microparticles magnetically active by a supercritical fluid based process |
| url | http://dx.doi.org/10.1155/2009/781247 |
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