Brain development during the lifespan of cynomolgus monkeys
The cynomolgus monkey has emerged as a predominant nonhuman primate model in neuroscience research. A comprehensive grasp of the growth and development patterns in the cynomolgus monkey brain is crucial for the judicious utilization of this species in neuroscience investigations. This project involv...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S105381192400449X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841546000621109248 |
|---|---|
| author | Zhiqiang Tan Binbin Nie Huanhua Wu Bang Li Jingjie Shang Tianhao Zhang Zeyu Xiao Chenchen Dong Chunyuan Zeng Biao Wu Lu Hou Bin Guo Yong Cheng Jian Gong Weijian Ye Lin Xu Yuefeng Li Xiaojiang Li Steven H. Liang Baoci Shan Hao Xu Lu Wang |
| author_facet | Zhiqiang Tan Binbin Nie Huanhua Wu Bang Li Jingjie Shang Tianhao Zhang Zeyu Xiao Chenchen Dong Chunyuan Zeng Biao Wu Lu Hou Bin Guo Yong Cheng Jian Gong Weijian Ye Lin Xu Yuefeng Li Xiaojiang Li Steven H. Liang Baoci Shan Hao Xu Lu Wang |
| author_sort | Zhiqiang Tan |
| collection | DOAJ |
| description | The cynomolgus monkey has emerged as a predominant nonhuman primate model in neuroscience research. A comprehensive grasp of the growth and development patterns in the cynomolgus monkey brain is crucial for the judicious utilization of this species in neuroscience investigations. This project involved the collection of brain [18F]FDG PET-MRI data from 228 healthy cynomolgus monkeys spanning the age range of 0.5–29.5 years to construct an age-specific multimodal image brain template toolset tailored to cynomolgus monkeys. Their brain volume and glucose metabolism were quantitatively analyzed by utilizing an individualized spatial segmentation algorithm. Our findings encapsulated the growth and development trends, sex differences, and asymmetrical variations in brain volume and glucose metabolism in cynomolgus monkeys, and analyzed the correlation between the brain volume and glucose metabolism. This endeavor enhances our capacity to leverage the cynomolgus monkey model in neuroscience research by providing a valuable resource for researchers. The age-specific brain template toolset and associated data offer a robust foundation for future investigations, facilitating a nuanced understanding of brain development in this primate species and, consequently, informing and advancing neuroscience research employing cynomolgus monkeys. |
| format | Article |
| id | doaj-art-a4ad333c746340e1ad3dfc115a71c164 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-a4ad333c746340e1ad3dfc115a71c1642025-01-11T06:38:30ZengElsevierNeuroImage1095-95722025-01-01305120952Brain development during the lifespan of cynomolgus monkeysZhiqiang Tan0Binbin Nie1Huanhua Wu2Bang Li3Jingjie Shang4Tianhao Zhang5Zeyu Xiao6Chenchen Dong7Chunyuan Zeng8Biao Wu9Lu Hou10Bin Guo11Yong Cheng12Jian Gong13Weijian Ye14Lin Xu15Yuefeng Li16Xiaojiang Li17Steven H. Liang18Baoci Shan19Hao Xu20Lu Wang21Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaBeijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences & School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, ChinaThe Affiliated Shunde Hospital of Jinan University, Foshan 528305, ChinaCollege of A&F Engineering and Planning, Tongren University, Tongren 554300, Guizhou, China; Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510630, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaBeijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences & School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, ChinaThe Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaCenter of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, ChinaKunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650223, ChinaGuangdong Landau Biotechnology Co. Ltd., Guangzhou 510555, ChinaGuangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou 510630, ChinaDepartment of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd, Atlanta, Georgia 30322, United StatesBeijing Engineering Research Center of Radiographic Techniques and Equipment, Institute of High Energy Physics, Chinese Academy of Sciences & School of Nuclear Science and Technology, University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding authors.Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; Corresponding authors.Center of PET/CT-MRI, Department of Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China; The Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Jinan University, Guangzhou 510632, China; Corresponding authors.The cynomolgus monkey has emerged as a predominant nonhuman primate model in neuroscience research. A comprehensive grasp of the growth and development patterns in the cynomolgus monkey brain is crucial for the judicious utilization of this species in neuroscience investigations. This project involved the collection of brain [18F]FDG PET-MRI data from 228 healthy cynomolgus monkeys spanning the age range of 0.5–29.5 years to construct an age-specific multimodal image brain template toolset tailored to cynomolgus monkeys. Their brain volume and glucose metabolism were quantitatively analyzed by utilizing an individualized spatial segmentation algorithm. Our findings encapsulated the growth and development trends, sex differences, and asymmetrical variations in brain volume and glucose metabolism in cynomolgus monkeys, and analyzed the correlation between the brain volume and glucose metabolism. This endeavor enhances our capacity to leverage the cynomolgus monkey model in neuroscience research by providing a valuable resource for researchers. The age-specific brain template toolset and associated data offer a robust foundation for future investigations, facilitating a nuanced understanding of brain development in this primate species and, consequently, informing and advancing neuroscience research employing cynomolgus monkeys.http://www.sciencedirect.com/science/article/pii/S105381192400449XBrain developmentCynomolgus monkey[18F]FDG PET-MRIVolumeGlucose metabolism |
| spellingShingle | Zhiqiang Tan Binbin Nie Huanhua Wu Bang Li Jingjie Shang Tianhao Zhang Zeyu Xiao Chenchen Dong Chunyuan Zeng Biao Wu Lu Hou Bin Guo Yong Cheng Jian Gong Weijian Ye Lin Xu Yuefeng Li Xiaojiang Li Steven H. Liang Baoci Shan Hao Xu Lu Wang Brain development during the lifespan of cynomolgus monkeys NeuroImage Brain development Cynomolgus monkey [18F]FDG PET-MRI Volume Glucose metabolism |
| title | Brain development during the lifespan of cynomolgus monkeys |
| title_full | Brain development during the lifespan of cynomolgus monkeys |
| title_fullStr | Brain development during the lifespan of cynomolgus monkeys |
| title_full_unstemmed | Brain development during the lifespan of cynomolgus monkeys |
| title_short | Brain development during the lifespan of cynomolgus monkeys |
| title_sort | brain development during the lifespan of cynomolgus monkeys |
| topic | Brain development Cynomolgus monkey [18F]FDG PET-MRI Volume Glucose metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S105381192400449X |
| work_keys_str_mv | AT zhiqiangtan braindevelopmentduringthelifespanofcynomolgusmonkeys AT binbinnie braindevelopmentduringthelifespanofcynomolgusmonkeys AT huanhuawu braindevelopmentduringthelifespanofcynomolgusmonkeys AT bangli braindevelopmentduringthelifespanofcynomolgusmonkeys AT jingjieshang braindevelopmentduringthelifespanofcynomolgusmonkeys AT tianhaozhang braindevelopmentduringthelifespanofcynomolgusmonkeys AT zeyuxiao braindevelopmentduringthelifespanofcynomolgusmonkeys AT chenchendong braindevelopmentduringthelifespanofcynomolgusmonkeys AT chunyuanzeng braindevelopmentduringthelifespanofcynomolgusmonkeys AT biaowu braindevelopmentduringthelifespanofcynomolgusmonkeys AT luhou braindevelopmentduringthelifespanofcynomolgusmonkeys AT binguo braindevelopmentduringthelifespanofcynomolgusmonkeys AT yongcheng braindevelopmentduringthelifespanofcynomolgusmonkeys AT jiangong braindevelopmentduringthelifespanofcynomolgusmonkeys AT weijianye braindevelopmentduringthelifespanofcynomolgusmonkeys AT linxu braindevelopmentduringthelifespanofcynomolgusmonkeys AT yuefengli braindevelopmentduringthelifespanofcynomolgusmonkeys AT xiaojiangli braindevelopmentduringthelifespanofcynomolgusmonkeys AT stevenhliang braindevelopmentduringthelifespanofcynomolgusmonkeys AT baocishan braindevelopmentduringthelifespanofcynomolgusmonkeys AT haoxu braindevelopmentduringthelifespanofcynomolgusmonkeys AT luwang braindevelopmentduringthelifespanofcynomolgusmonkeys |