Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 Infection
In a preventive context, natural peptides can play a major role against SARS-CoV-2, so their character of GRAS (generally recognized as safe) means they would not need innocuity analyses to be employed. This study analyses the potential of pea peptides, LSDRFS and SDRFSY, and amaranth peptides, GGV,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Food Quality |
| Online Access: | http://dx.doi.org/10.1155/2022/2102937 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849399926530768896 |
|---|---|
| author | María Paredes-Ramos Enma Conde Piñeiro Horacio Pérez-Sánchez José M. López-Vilariño |
| author_facet | María Paredes-Ramos Enma Conde Piñeiro Horacio Pérez-Sánchez José M. López-Vilariño |
| author_sort | María Paredes-Ramos |
| collection | DOAJ |
| description | In a preventive context, natural peptides can play a major role against SARS-CoV-2, so their character of GRAS (generally recognized as safe) means they would not need innocuity analyses to be employed. This study analyses the potential of pea peptides, LSDRFS and SDRFSY, and amaranth peptides, GGV, IGV, IVG, VGVL, and VIKP, against the SARS-CoV-2 hosts, ACE2 (angiotensin-converting enzyme 2), ACE (angiotensin-converting enzyme), and CD26 (cluster of differentiation 26), and SARS-CoV-2 enzymes, spike glycoprotein and 3CLpro (3-chymotrypsin-like protease). Also, currently used drugs were analysed to contrast drug and peptide behaviour. Employing docking, virtual screening, and molecular dynamics assays, SDRFSY, LSDRFS, and VIKP were detected as potential bioactive peptides by blocking ACE2 and CD26 or reducing the inflammation associated with COVID-19. Enzyme inhibition analyses were also performed, proving the ability of SDRFSY and LSDRFS as ACE2-blocking agents against the spike glycoprotein with inhibition capacities above 80%. |
| format | Article |
| id | doaj-art-a4aa9dc9da4b4cc1921b0ed3ff0bae8c |
| institution | Kabale University |
| issn | 1745-4557 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Food Quality |
| spelling | doaj-art-a4aa9dc9da4b4cc1921b0ed3ff0bae8c2025-08-20T03:38:13ZengWileyJournal of Food Quality1745-45572022-01-01202210.1155/2022/2102937Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 InfectionMaría Paredes-Ramos0Enma Conde Piñeiro1Horacio Pérez-Sánchez2José M. López-Vilariño3METMED Research GroupGLECEX (Global and Ecofriendly Natural Extracts S.L.)Structural Bioinformatics and High-Performance Computing Research Group (BIO-HPC)Hijos de Rivera S.A.U.In a preventive context, natural peptides can play a major role against SARS-CoV-2, so their character of GRAS (generally recognized as safe) means they would not need innocuity analyses to be employed. This study analyses the potential of pea peptides, LSDRFS and SDRFSY, and amaranth peptides, GGV, IGV, IVG, VGVL, and VIKP, against the SARS-CoV-2 hosts, ACE2 (angiotensin-converting enzyme 2), ACE (angiotensin-converting enzyme), and CD26 (cluster of differentiation 26), and SARS-CoV-2 enzymes, spike glycoprotein and 3CLpro (3-chymotrypsin-like protease). Also, currently used drugs were analysed to contrast drug and peptide behaviour. Employing docking, virtual screening, and molecular dynamics assays, SDRFSY, LSDRFS, and VIKP were detected as potential bioactive peptides by blocking ACE2 and CD26 or reducing the inflammation associated with COVID-19. Enzyme inhibition analyses were also performed, proving the ability of SDRFSY and LSDRFS as ACE2-blocking agents against the spike glycoprotein with inhibition capacities above 80%.http://dx.doi.org/10.1155/2022/2102937 |
| spellingShingle | María Paredes-Ramos Enma Conde Piñeiro Horacio Pérez-Sánchez José M. López-Vilariño Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 Infection Journal of Food Quality |
| title | Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 Infection |
| title_full | Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 Infection |
| title_fullStr | Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 Infection |
| title_full_unstemmed | Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 Infection |
| title_short | Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 Infection |
| title_sort | evaluation of natural peptides to prevent and reduce the novel sars cov 2 infection |
| url | http://dx.doi.org/10.1155/2022/2102937 |
| work_keys_str_mv | AT mariaparedesramos evaluationofnaturalpeptidestopreventandreducethenovelsarscov2infection AT enmacondepineiro evaluationofnaturalpeptidestopreventandreducethenovelsarscov2infection AT horacioperezsanchez evaluationofnaturalpeptidestopreventandreducethenovelsarscov2infection AT josemlopezvilarino evaluationofnaturalpeptidestopreventandreducethenovelsarscov2infection |