Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study
Abstract Background This study aims to compare the mortality rates of OHCA patients with and without COVID-19 infection across different follow-up periods and explores the factors may play a significant role in determining OHCA outcomes. Methods This study utilized data from the US Collaborative Net...
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BMC
2025-05-01
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| Series: | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine |
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| Online Access: | https://doi.org/10.1186/s13049-025-01395-2 |
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| author | Nai-Chen Shih Han-Wei Yeh Shun-Fa Yang Yu-Hsun Wang Chung-Hsien Chaou Chao-Bin Yeh |
| author_facet | Nai-Chen Shih Han-Wei Yeh Shun-Fa Yang Yu-Hsun Wang Chung-Hsien Chaou Chao-Bin Yeh |
| author_sort | Nai-Chen Shih |
| collection | DOAJ |
| description | Abstract Background This study aims to compare the mortality rates of OHCA patients with and without COVID-19 infection across different follow-up periods and explores the factors may play a significant role in determining OHCA outcomes. Methods This study utilized data from the US Collaborative Network in TriNetX. A total of 25,271 hospitalized OHCA patients were recruited from records spanning from January 1, 2020, to December 31, 2023. Study population divided into two groups, COVID-19 positive and COVID-19 negative groups. The mortality risk of the two groups was observed based on different follow-up periods. Subgroup analyses on sex, age, antivirals use, COVID-19 virus variant epidemic period were also conducted. Results Our study included 2,776 patients in each group (COVID vs. non-COVID). The primary outcome was mortality at 14-day and 90-day follow-ups. COVID-19 patients had a lower 14-day mortality (HR 0.82, 95% CI: 0.76–0.88) but higher 90-day mortality (HR 1.16, 95% CI: 1.09–1.24) compared to non-COVID-19 patients. Secondary outcomes included higher mortality in COVID-19 patients under 65, and this trend persisted in those aged 65 and over. Male COVID-19 patients had elevated mortality risk. The Alpha and Delta variant period showed a higher mortality rate for COVID-19 patients than non-COVID-19 patients. Conclusion COVID-19 was associated with a higher risk of mortality in OHCA patients. |
| format | Article |
| id | doaj-art-a4aa1f1de6c947b99a347c1e1d4d7b35 |
| institution | DOAJ |
| issn | 1757-7241 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine |
| spelling | doaj-art-a4aa1f1de6c947b99a347c1e1d4d7b352025-08-20T02:55:28ZengBMCScandinavian Journal of Trauma, Resuscitation and Emergency Medicine1757-72412025-05-013311910.1186/s13049-025-01395-2Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort studyNai-Chen Shih0Han-Wei Yeh1Shun-Fa Yang2Yu-Hsun Wang3Chung-Hsien Chaou4Chao-Bin Yeh5Institute of Medicine, Chung Shan Medical UniversityDepartment of Emergency Medicine, Linkou Chang Gung Memorial HospitalInstitute of Medicine, Chung Shan Medical UniversityInstitute of Medicine, Chung Shan Medical UniversityDepartment of Emergency Medicine, Linkou Chang Gung Memorial HospitalInstitute of Medicine, Chung Shan Medical UniversityAbstract Background This study aims to compare the mortality rates of OHCA patients with and without COVID-19 infection across different follow-up periods and explores the factors may play a significant role in determining OHCA outcomes. Methods This study utilized data from the US Collaborative Network in TriNetX. A total of 25,271 hospitalized OHCA patients were recruited from records spanning from January 1, 2020, to December 31, 2023. Study population divided into two groups, COVID-19 positive and COVID-19 negative groups. The mortality risk of the two groups was observed based on different follow-up periods. Subgroup analyses on sex, age, antivirals use, COVID-19 virus variant epidemic period were also conducted. Results Our study included 2,776 patients in each group (COVID vs. non-COVID). The primary outcome was mortality at 14-day and 90-day follow-ups. COVID-19 patients had a lower 14-day mortality (HR 0.82, 95% CI: 0.76–0.88) but higher 90-day mortality (HR 1.16, 95% CI: 1.09–1.24) compared to non-COVID-19 patients. Secondary outcomes included higher mortality in COVID-19 patients under 65, and this trend persisted in those aged 65 and over. Male COVID-19 patients had elevated mortality risk. The Alpha and Delta variant period showed a higher mortality rate for COVID-19 patients than non-COVID-19 patients. Conclusion COVID-19 was associated with a higher risk of mortality in OHCA patients.https://doi.org/10.1186/s13049-025-01395-2COVID-19 infectionOut-of-hospital cardiac arrestMortalityRetrospective cohort study |
| spellingShingle | Nai-Chen Shih Han-Wei Yeh Shun-Fa Yang Yu-Hsun Wang Chung-Hsien Chaou Chao-Bin Yeh Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine COVID-19 infection Out-of-hospital cardiac arrest Mortality Retrospective cohort study |
| title | Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study |
| title_full | Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study |
| title_fullStr | Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study |
| title_full_unstemmed | Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study |
| title_short | Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study |
| title_sort | impact of covid 19 on mortality in out of hospital cardiac arrest patients with return of spontaneous circulation a retrospective cohort study |
| topic | COVID-19 infection Out-of-hospital cardiac arrest Mortality Retrospective cohort study |
| url | https://doi.org/10.1186/s13049-025-01395-2 |
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