An in silico to in vivo approach identifies retinoid-X receptor activating tert-butylphenols used in food contact materials

An in silico to in vivo approach identifies retinoid-X receptor activating tert-butylphenols used in food contact materials

Abstract The potential for food contact chemicals to disrupt genetic programs in development and metabolism raises concerns. Nuclear receptors (NRs) control many of these programs, and the retinoid-X receptor (RXR) is a DNA-binding partner for one-third of the NRs. RXR disruption could generate adve...

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Bibliographic Details
Main Authors: Brenda J. Mengeling, Azhagiya Singam Ettayapuram Ramaprasad, Martyn T. Smith, Dania Turkieh, Nicole C. Kleinstreuer, Kamel Mansouri, Kathleen A. Durkin, Michele A. La Merrill, J. David Furlow
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Retinoid-X receptor
Molecular docking
Environmental exposure
Food contact chemicals
Machine learning
Artificial intelligence
Online Access:https://doi.org/10.1038/s41598-025-09244-z
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