Target Points in Trastuzumab Resistance
Epidermal growth factor (EGF) family of receptors is involved in cell growth and differentiation. The human EGF2 (HER2) lacks natural ligands, and correlation between HER2 levels and carcinogenesis makes the receptor an ideal candidate for targeted therapy in breast cancer. Trastuzumab is a humanize...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/761917 |
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| _version_ | 1849399840869449728 |
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| author | Sahar Shojaei Mossa Gardaneh Abbas Rahimi Shamabadi |
| author_facet | Sahar Shojaei Mossa Gardaneh Abbas Rahimi Shamabadi |
| author_sort | Sahar Shojaei |
| collection | DOAJ |
| description | Epidermal growth factor (EGF) family of receptors is involved in cell growth and differentiation. The human EGF2 (HER2) lacks natural ligands, and correlation between HER2 levels and carcinogenesis makes the receptor an ideal candidate for targeted therapy in breast cancer. Trastuzumab is a humanized antibody applied against HER2-positive breast tumors in clinic. Metastatic tumors respond well to trastuzumab therapy for the first year, but development of antibody resistance helps the tumors to regrow allowing the disease to progress. Trastuzumab resistance is shaped via a range of intracellular signaling pathways that are interconnected and share in key effector molecules. Identification of a common node central to these resistance pathways could provide an ultimate solution for trastuzumab resistance in breast and other cancers. |
| format | Article |
| id | doaj-art-a49dfb286f214a8694509f78442bef4d |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-a49dfb286f214a8694509f78442bef4d2025-08-20T03:38:14ZengWileyInternational Journal of Breast Cancer2090-31702090-31892012-01-01201210.1155/2012/761917761917Target Points in Trastuzumab ResistanceSahar Shojaei0Mossa Gardaneh1Abbas Rahimi Shamabadi2National Institute of Genetic Engineering and Biotechnology (NIGEB), Pajoohesh Boulevard, Tehran-Karaj HWY, Km 15, Tehran 1497716316, IranNational Institute of Genetic Engineering and Biotechnology (NIGEB), Pajoohesh Boulevard, Tehran-Karaj HWY, Km 15, Tehran 1497716316, IranNational Institute of Genetic Engineering and Biotechnology (NIGEB), Pajoohesh Boulevard, Tehran-Karaj HWY, Km 15, Tehran 1497716316, IranEpidermal growth factor (EGF) family of receptors is involved in cell growth and differentiation. The human EGF2 (HER2) lacks natural ligands, and correlation between HER2 levels and carcinogenesis makes the receptor an ideal candidate for targeted therapy in breast cancer. Trastuzumab is a humanized antibody applied against HER2-positive breast tumors in clinic. Metastatic tumors respond well to trastuzumab therapy for the first year, but development of antibody resistance helps the tumors to regrow allowing the disease to progress. Trastuzumab resistance is shaped via a range of intracellular signaling pathways that are interconnected and share in key effector molecules. Identification of a common node central to these resistance pathways could provide an ultimate solution for trastuzumab resistance in breast and other cancers.http://dx.doi.org/10.1155/2012/761917 |
| spellingShingle | Sahar Shojaei Mossa Gardaneh Abbas Rahimi Shamabadi Target Points in Trastuzumab Resistance International Journal of Breast Cancer |
| title | Target Points in Trastuzumab Resistance |
| title_full | Target Points in Trastuzumab Resistance |
| title_fullStr | Target Points in Trastuzumab Resistance |
| title_full_unstemmed | Target Points in Trastuzumab Resistance |
| title_short | Target Points in Trastuzumab Resistance |
| title_sort | target points in trastuzumab resistance |
| url | http://dx.doi.org/10.1155/2012/761917 |
| work_keys_str_mv | AT saharshojaei targetpointsintrastuzumabresistance AT mossagardaneh targetpointsintrastuzumabresistance AT abbasrahimishamabadi targetpointsintrastuzumabresistance |