Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes
Abstract Metabolic syndrome is a significant risk factor for poor graft outcomes in kidney transplant (KT) patients. However, the effects of variability in metabolic parameters on graft outcomes in KT patients have not been completely elucidated. A total of 852 KT patients were included from the Kor...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-78079-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850196471560798208 |
|---|---|
| author | Hyo Jeong Kim Kyung Won Kim Cheol Woong Jung Jun Young Lee Ji Yoon Choi Beom Seok Kim Myoung Soo Kim Jaeseok Yang |
| author_facet | Hyo Jeong Kim Kyung Won Kim Cheol Woong Jung Jun Young Lee Ji Yoon Choi Beom Seok Kim Myoung Soo Kim Jaeseok Yang |
| author_sort | Hyo Jeong Kim |
| collection | DOAJ |
| description | Abstract Metabolic syndrome is a significant risk factor for poor graft outcomes in kidney transplant (KT) patients. However, the effects of variability in metabolic parameters on graft outcomes in KT patients have not been completely elucidated. A total of 852 KT patients were included from the Korean Organ Transplantation Registry. The study exposure was variability in body mass index (BMI) or other metabolic parameters measured at 6 months, 1 year, and 2 years after KT. Patients were classified into tertiles according to the degree of variability. The primary outcome was a composite of adverse kidney outcomes, such as death-censored graft loss or ≥ 30% decline in estimated glomerular filtration rate. The adverse kidney outcomes occurred in 73 (8.6%) participants. The high-BMI variability group had a higher risk for adverse kidney outcomes compared to the low-variability group. High variabilities in triglyceride, fasting blood glucose, and systolic blood pressure were also associated with adverse kidney outcomes. Furthermore, high variability in metabolic syndrome-related composite indices, such as the triglyceride and glucose index and metabolic variability scores, showed a higher risk for adverse kidney outcomes. In conclusion, high variability in metabolic parameters could be associated with an increased risk of adverse kidney outcome in KT patients. |
| format | Article |
| id | doaj-art-a49c2e4865e14fdf8c3f522f29d91144 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-a49c2e4865e14fdf8c3f522f29d911442025-08-20T02:13:27ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-78079-xAssociation of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomesHyo Jeong Kim0Kyung Won Kim1Cheol Woong Jung2Jun Young Lee3Ji Yoon Choi4Beom Seok Kim5Myoung Soo Kim6Jaeseok Yang7Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Internal Medicine, Korea University Guro Hospital, Korea University College of MedicineDepartment of Surgery, Korea University College of MedicineDepartment of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University College of MedicineDepartment of Surgery, Hanyang University Medical CenterDivision of Nephrology, Department of Internal Medicine, College of Medicine, Yonsei UniversityDepartment of Surgery, Severance Hospital, Yonsei University College of MedicineDepartment of Internal Medicine, Korea University Guro Hospital, Korea University College of MedicineAbstract Metabolic syndrome is a significant risk factor for poor graft outcomes in kidney transplant (KT) patients. However, the effects of variability in metabolic parameters on graft outcomes in KT patients have not been completely elucidated. A total of 852 KT patients were included from the Korean Organ Transplantation Registry. The study exposure was variability in body mass index (BMI) or other metabolic parameters measured at 6 months, 1 year, and 2 years after KT. Patients were classified into tertiles according to the degree of variability. The primary outcome was a composite of adverse kidney outcomes, such as death-censored graft loss or ≥ 30% decline in estimated glomerular filtration rate. The adverse kidney outcomes occurred in 73 (8.6%) participants. The high-BMI variability group had a higher risk for adverse kidney outcomes compared to the low-variability group. High variabilities in triglyceride, fasting blood glucose, and systolic blood pressure were also associated with adverse kidney outcomes. Furthermore, high variability in metabolic syndrome-related composite indices, such as the triglyceride and glucose index and metabolic variability scores, showed a higher risk for adverse kidney outcomes. In conclusion, high variability in metabolic parameters could be associated with an increased risk of adverse kidney outcome in KT patients.https://doi.org/10.1038/s41598-024-78079-x |
| spellingShingle | Hyo Jeong Kim Kyung Won Kim Cheol Woong Jung Jun Young Lee Ji Yoon Choi Beom Seok Kim Myoung Soo Kim Jaeseok Yang Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes Scientific Reports |
| title | Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes |
| title_full | Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes |
| title_fullStr | Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes |
| title_full_unstemmed | Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes |
| title_short | Association of variabilities in body mass index and metabolic parameters with post-kidney transplantation renal outcomes |
| title_sort | association of variabilities in body mass index and metabolic parameters with post kidney transplantation renal outcomes |
| url | https://doi.org/10.1038/s41598-024-78079-x |
| work_keys_str_mv | AT hyojeongkim associationofvariabilitiesinbodymassindexandmetabolicparameterswithpostkidneytransplantationrenaloutcomes AT kyungwonkim associationofvariabilitiesinbodymassindexandmetabolicparameterswithpostkidneytransplantationrenaloutcomes AT cheolwoongjung associationofvariabilitiesinbodymassindexandmetabolicparameterswithpostkidneytransplantationrenaloutcomes AT junyounglee associationofvariabilitiesinbodymassindexandmetabolicparameterswithpostkidneytransplantationrenaloutcomes AT jiyoonchoi associationofvariabilitiesinbodymassindexandmetabolicparameterswithpostkidneytransplantationrenaloutcomes AT beomseokkim associationofvariabilitiesinbodymassindexandmetabolicparameterswithpostkidneytransplantationrenaloutcomes AT myoungsookim associationofvariabilitiesinbodymassindexandmetabolicparameterswithpostkidneytransplantationrenaloutcomes AT jaeseokyang associationofvariabilitiesinbodymassindexandmetabolicparameterswithpostkidneytransplantationrenaloutcomes |