Evaluation of newly synthesized schiff base Pd(II) complexes for prostate cancer treatment through in vitro cytotoxicity and molecular mechanistic studies

Evaluation of newly synthesized schiff base Pd(II) complexes for prostate cancer treatment through in vitro cytotoxicity and molecular mechanistic studies

IntroductionPalladium (II) complexes are promising anticancer agents with potential advantages over platinum drugs. This study aimed to synthesize and characterize three new Pd(II) complexes (2a–2c) with Schiff base ligands derived from salicylic acid and amine scaffolds, and to evaluate their antit...

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Main Authors: Damnjan Pantic, Nikola Mirkovic, Tatjana Vulovic, Danijela Jovanovic, Stefan Jakovljevic, Petar Canovic, Milan Zaric, Radica Zivkovic Zaric, Marina Kostic, Jovana Dragojevic, Vera Divac, Ziko Milanovic, Kristina Milisavljevic, Marina Mitrovic, Ivanka Zelen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Chemistry
Subjects:
palladium
schiff bases
DNA
albumin
cytotoxicity
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1636477/full
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