Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure
Relevance. COVID-19, caused by the SARS-CoV-2 virus, remains a global public health threat despite the end of the pandemic. In the four years since the onset of the pandemic, the SARS-CoV-2 genome has undergone significant changes, particularly in the gene encoding the spike (S) protein. These chang...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2025-01-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/2132 |
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| author | S. K. Pylaeva A. A. Sinyugina L. I. Kozlovskaya E. A. Artamonova A. A. Erovichenkov R. F. Sayfullin I. V. Gordeychuk A. A Ishmukhametov |
| author_facet | S. K. Pylaeva A. A. Sinyugina L. I. Kozlovskaya E. A. Artamonova A. A. Erovichenkov R. F. Sayfullin I. V. Gordeychuk A. A Ishmukhametov |
| author_sort | S. K. Pylaeva |
| collection | DOAJ |
| description | Relevance. COVID-19, caused by the SARS-CoV-2 virus, remains a global public health threat despite the end of the pandemic. In the four years since the onset of the pandemic, the SARS-CoV-2 genome has undergone significant changes, particularly in the gene encoding the spike (S) protein. These changes resulted from the accumulation of immune responses in the human population, allowing the virus to evade the immune response. A significant proportion of the population was infected early in the pandemic or vaccinated with vaccines based on earlier variants of the virus. The emergence of new mutant variants raises concerns about the potential for severe COVID-19 in previously infected or vaccinated individuals.Аim. To examine the specifics of antibody formation, as well as the spectrum and functional activity of these antibodies in patients with COVID-19.Conclusions. Antibodies produced in response to infection or vaccination show diversity in spectrum and functional activity. Changes in the viral genome may reduce antibody effectiveness, highlighting the importance of monitoring new SARS-CoV-2 variants and developing adapted vaccines. These data will be key in shaping COVID-19 vaccination and treatment strategies in a changing epidemiological situation. |
| format | Article |
| id | doaj-art-a496eb1cec844fbeaae2c8625de5a949 |
| institution | DOAJ |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-a496eb1cec844fbeaae2c8625de5a9492025-08-20T02:55:54ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942025-01-0123616917610.31631/2073-3046-2024-23-6-169-1761092Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structureS. K. Pylaeva0A. A. Sinyugina1L. I. Kozlovskaya2E. A. Artamonova3A. A. Erovichenkov4R. F. Sayfullin5I. V. Gordeychuk6A. A Ishmukhametov7M.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences (Polio Institute); Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationM.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences (Polio Institute)M.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences (Polio Institute); Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University)M.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences (Polio Institute)M.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences (Polio Institute)Pirogov Russian National Research Medical University of the Ministry of Health of the Russian FederationM.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences (Polio Institute); Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University)M.P. Chumakov Federal Scientific Center for Research and Development of Immunobiological Drugs of the Russian Academy of Sciences (Polio Institute); Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation (Sechenov University)Relevance. COVID-19, caused by the SARS-CoV-2 virus, remains a global public health threat despite the end of the pandemic. In the four years since the onset of the pandemic, the SARS-CoV-2 genome has undergone significant changes, particularly in the gene encoding the spike (S) protein. These changes resulted from the accumulation of immune responses in the human population, allowing the virus to evade the immune response. A significant proportion of the population was infected early in the pandemic or vaccinated with vaccines based on earlier variants of the virus. The emergence of new mutant variants raises concerns about the potential for severe COVID-19 in previously infected or vaccinated individuals.Аim. To examine the specifics of antibody formation, as well as the spectrum and functional activity of these antibodies in patients with COVID-19.Conclusions. Antibodies produced in response to infection or vaccination show diversity in spectrum and functional activity. Changes in the viral genome may reduce antibody effectiveness, highlighting the importance of monitoring new SARS-CoV-2 variants and developing adapted vaccines. These data will be key in shaping COVID-19 vaccination and treatment strategies in a changing epidemiological situation.https://www.epidemvac.ru/jour/article/view/2132sars-cov-2covid-19serological testneutralizing antibodiesnatbinding antibodies |
| spellingShingle | S. K. Pylaeva A. A. Sinyugina L. I. Kozlovskaya E. A. Artamonova A. A. Erovichenkov R. F. Sayfullin I. V. Gordeychuk A. A Ishmukhametov Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure Эпидемиология и вакцинопрофилактика sars-cov-2 covid-19 serological test neutralizing antibodies nat binding antibodies |
| title | Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure |
| title_full | Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure |
| title_fullStr | Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure |
| title_full_unstemmed | Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure |
| title_short | Neutralising and Non-neutralising Antibodies to SARS-CoV-2: Role during Infection and in the Evolution of Antigenic structure |
| title_sort | neutralising and non neutralising antibodies to sars cov 2 role during infection and in the evolution of antigenic structure |
| topic | sars-cov-2 covid-19 serological test neutralizing antibodies nat binding antibodies |
| url | https://www.epidemvac.ru/jour/article/view/2132 |
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