Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species
The methanol extracts of three Macaranga species (M. denticulata, M. pruinosa, and M. gigantea) were screened to evaluate their total phenolic contents and activities as cholinesterase inhibitors, nitric oxide (NO) production inhibitors, tyrosinase inhibitors, and antioxidants. The bark of M. dentic...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/312741 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850160847824879616 |
|---|---|
| author | Nor Aishah Mazlan Ahmed Mediani Faridah Abas Syahida Ahmad Khozirah Shaari Shamsul Khamis N. H. Lajis |
| author_facet | Nor Aishah Mazlan Ahmed Mediani Faridah Abas Syahida Ahmad Khozirah Shaari Shamsul Khamis N. H. Lajis |
| author_sort | Nor Aishah Mazlan |
| collection | DOAJ |
| description | The methanol extracts of three Macaranga species (M. denticulata, M. pruinosa, and M. gigantea) were screened to evaluate their total phenolic contents and activities as cholinesterase inhibitors, nitric oxide (NO) production inhibitors, tyrosinase inhibitors, and antioxidants. The bark of M. denticulata showed the highest total phenolic content (2682 mg gallic acid equivalent (GAE)/100 g) and free radical scavenging activity (IC50 = 0.063 mg/mL). All of the samples inhibited linoleic acid peroxidation by greater than 80%, with the leaves of M. gigantea exhibiting the highest inhibition of 92.21%. Most of the samples exhibited significant antioxidant potential. The bark of M. denticulata and the leaves of both M. pruinosa and M. gigantea exhibited greater than 50% tyrosinase inhibition, with the bark of M. denticulata having the highest percentage of inhibition (68.7%). The bark and leaves of M. denticulata exhibited greater than 50% inhibition (73.82% and 54.50%, resp.) of the acetylcholinesterase enzyme (AChE), while none of the samples showed any significant inhibition of butyrylcholinesterase (BChE). Only the bark of M. denticulata and M. gigantea displayed greater than 50% inhibition of nitric oxide production in cells (81.79% and 56.51%, resp.). These bioactivities indicate that some Macaranga spp. have therapeutic potential in medicinal research. |
| format | Article |
| id | doaj-art-a495fd9fee314d569451d7d84c35dd2a |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-a495fd9fee314d569451d7d84c35dd2a2025-08-20T02:23:04ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/312741312741Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga SpeciesNor Aishah Mazlan0Ahmed Mediani1Faridah Abas2Syahida Ahmad3Khozirah Shaari4Shamsul Khamis5N. H. Lajis6Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaDepartment of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaLaboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaLaboratory of Natural Products, Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaAl-Moalim Bin Laden Chair for Scientific Miracles of Prophetic Medicine, Scientific Chairs Unit, Taibah University, P.O. Box 30001, Madinah al Munawarah 41311, Saudi ArabiaThe methanol extracts of three Macaranga species (M. denticulata, M. pruinosa, and M. gigantea) were screened to evaluate their total phenolic contents and activities as cholinesterase inhibitors, nitric oxide (NO) production inhibitors, tyrosinase inhibitors, and antioxidants. The bark of M. denticulata showed the highest total phenolic content (2682 mg gallic acid equivalent (GAE)/100 g) and free radical scavenging activity (IC50 = 0.063 mg/mL). All of the samples inhibited linoleic acid peroxidation by greater than 80%, with the leaves of M. gigantea exhibiting the highest inhibition of 92.21%. Most of the samples exhibited significant antioxidant potential. The bark of M. denticulata and the leaves of both M. pruinosa and M. gigantea exhibited greater than 50% tyrosinase inhibition, with the bark of M. denticulata having the highest percentage of inhibition (68.7%). The bark and leaves of M. denticulata exhibited greater than 50% inhibition (73.82% and 54.50%, resp.) of the acetylcholinesterase enzyme (AChE), while none of the samples showed any significant inhibition of butyrylcholinesterase (BChE). Only the bark of M. denticulata and M. gigantea displayed greater than 50% inhibition of nitric oxide production in cells (81.79% and 56.51%, resp.). These bioactivities indicate that some Macaranga spp. have therapeutic potential in medicinal research.http://dx.doi.org/10.1155/2013/312741 |
| spellingShingle | Nor Aishah Mazlan Ahmed Mediani Faridah Abas Syahida Ahmad Khozirah Shaari Shamsul Khamis N. H. Lajis Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species The Scientific World Journal |
| title | Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species |
| title_full | Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species |
| title_fullStr | Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species |
| title_full_unstemmed | Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species |
| title_short | Antioxidant, Antityrosinase, Anticholinesterase, and Nitric Oxide Inhibition Activities of Three Malaysian Macaranga Species |
| title_sort | antioxidant antityrosinase anticholinesterase and nitric oxide inhibition activities of three malaysian macaranga species |
| url | http://dx.doi.org/10.1155/2013/312741 |
| work_keys_str_mv | AT noraishahmazlan antioxidantantityrosinaseanticholinesteraseandnitricoxideinhibitionactivitiesofthreemalaysianmacarangaspecies AT ahmedmediani antioxidantantityrosinaseanticholinesteraseandnitricoxideinhibitionactivitiesofthreemalaysianmacarangaspecies AT faridahabas antioxidantantityrosinaseanticholinesteraseandnitricoxideinhibitionactivitiesofthreemalaysianmacarangaspecies AT syahidaahmad antioxidantantityrosinaseanticholinesteraseandnitricoxideinhibitionactivitiesofthreemalaysianmacarangaspecies AT khozirahshaari antioxidantantityrosinaseanticholinesteraseandnitricoxideinhibitionactivitiesofthreemalaysianmacarangaspecies AT shamsulkhamis antioxidantantityrosinaseanticholinesteraseandnitricoxideinhibitionactivitiesofthreemalaysianmacarangaspecies AT nhlajis antioxidantantityrosinaseanticholinesteraseandnitricoxideinhibitionactivitiesofthreemalaysianmacarangaspecies |