Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood
ABSTRACT Objective: To highlight the importance of early recognition of hypopigmented mycosis fungoides (HMF) in cases of cutaneous hypochromia in children, with a view to an effective diagnostic and therapeutic approach. Case description: Two cases of HMF in children are reported. The first case...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade de Pediatria de São Paulo
2025-01-01
|
| Series: | Revista Paulista de Pediatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822025000100607&lng=en&tlng=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832592520685551616 |
|---|---|
| author | Maria Fernanda de Almeida Cavalcante Aranha Maria Amélia Lopes dos Santos Carla Andréa Avelar Pires Leônidas Braga Dias Júnior Rafaela Garcia Pereira Marina Lopes de Freitas Freire Tamara Tavares da Cruz Luiza Rennó Rocha de Oliveira |
| author_facet | Maria Fernanda de Almeida Cavalcante Aranha Maria Amélia Lopes dos Santos Carla Andréa Avelar Pires Leônidas Braga Dias Júnior Rafaela Garcia Pereira Marina Lopes de Freitas Freire Tamara Tavares da Cruz Luiza Rennó Rocha de Oliveira |
| author_sort | Maria Fernanda de Almeida Cavalcante Aranha |
| collection | DOAJ |
| description | ABSTRACT Objective: To highlight the importance of early recognition of hypopigmented mycosis fungoides (HMF) in cases of cutaneous hypochromia in children, with a view to an effective diagnostic and therapeutic approach. Case description: Two cases of HMF in children are reported. The first case involves an eight-year-old boy with hypochromic macules on the trunk and root of the upper and lower limbs, while the second case is a six-year-old boy with widespread hypochromic patches. Both patients presented with prolonged evolution of hypopigmentation, leading to the suspicion of HMF after excluding other differential diagnoses. Histopathological and immunohistochemical tests were fundamental in confirming the diagnosis of HMF. Comments: HMF is a less prevalent and less publicized form of mycosis fungoides and is more common in children and people with a high phototype. Its diagnosis is challenging and often requires multiple biopsies for confirmation. Treatment includes phototherapy and immunosuppressive therapy, depending on the patient’s age and extent of lesions. Early recognition of HMF is crucial for proper management and to avoid complications associated with malignant evolution. |
| format | Article |
| id | doaj-art-a490f515ecc04211837a629509066542 |
| institution | Kabale University |
| issn | 1984-0462 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Sociedade de Pediatria de São Paulo |
| record_format | Article |
| series | Revista Paulista de Pediatria |
| spelling | doaj-art-a490f515ecc04211837a6295090665422025-01-21T07:41:51ZengSociedade de Pediatria de São PauloRevista Paulista de Pediatria1984-04622025-01-014310.1590/1984-0462/2025/43/2024181Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhoodMaria Fernanda de Almeida Cavalcante Aranhahttps://orcid.org/0000-0002-5994-7122Maria Amélia Lopes dos Santoshttps://orcid.org/0000-0001-8606-6948Carla Andréa Avelar Pireshttps://orcid.org/0000-0002-0566-9921Leônidas Braga Dias Júniorhttps://orcid.org/0000-0002-3549-8078Rafaela Garcia Pereirahttps://orcid.org/0009-0009-6919-779XMarina Lopes de Freitas Freirehttps://orcid.org/0000-0002-4905-7441Tamara Tavares da Cruzhttps://orcid.org/0009-0002-2666-3083Luiza Rennó Rocha de Oliveirahttps://orcid.org/0009-0009-2878-949XABSTRACT Objective: To highlight the importance of early recognition of hypopigmented mycosis fungoides (HMF) in cases of cutaneous hypochromia in children, with a view to an effective diagnostic and therapeutic approach. Case description: Two cases of HMF in children are reported. The first case involves an eight-year-old boy with hypochromic macules on the trunk and root of the upper and lower limbs, while the second case is a six-year-old boy with widespread hypochromic patches. Both patients presented with prolonged evolution of hypopigmentation, leading to the suspicion of HMF after excluding other differential diagnoses. Histopathological and immunohistochemical tests were fundamental in confirming the diagnosis of HMF. Comments: HMF is a less prevalent and less publicized form of mycosis fungoides and is more common in children and people with a high phototype. Its diagnosis is challenging and often requires multiple biopsies for confirmation. Treatment includes phototherapy and immunosuppressive therapy, depending on the patient’s age and extent of lesions. Early recognition of HMF is crucial for proper management and to avoid complications associated with malignant evolution.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822025000100607&lng=en&tlng=enMycosis fungoidesDiagnosis, differentialDermatologyChild |
| spellingShingle | Maria Fernanda de Almeida Cavalcante Aranha Maria Amélia Lopes dos Santos Carla Andréa Avelar Pires Leônidas Braga Dias Júnior Rafaela Garcia Pereira Marina Lopes de Freitas Freire Tamara Tavares da Cruz Luiza Rennó Rocha de Oliveira Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood Revista Paulista de Pediatria Mycosis fungoides Diagnosis, differential Dermatology Child |
| title | Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood |
| title_full | Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood |
| title_fullStr | Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood |
| title_full_unstemmed | Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood |
| title_short | Hypopigmented mycosis fungoides: an important differential diagnosis of hypochromias in childhood |
| title_sort | hypopigmented mycosis fungoides an important differential diagnosis of hypochromias in childhood |
| topic | Mycosis fungoides Diagnosis, differential Dermatology Child |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822025000100607&lng=en&tlng=en |
| work_keys_str_mv | AT mariafernandadealmeidacavalcantearanha hypopigmentedmycosisfungoidesanimportantdifferentialdiagnosisofhypochromiasinchildhood AT mariaamelialopesdossantos hypopigmentedmycosisfungoidesanimportantdifferentialdiagnosisofhypochromiasinchildhood AT carlaandreaavelarpires hypopigmentedmycosisfungoidesanimportantdifferentialdiagnosisofhypochromiasinchildhood AT leonidasbragadiasjunior hypopigmentedmycosisfungoidesanimportantdifferentialdiagnosisofhypochromiasinchildhood AT rafaelagarciapereira hypopigmentedmycosisfungoidesanimportantdifferentialdiagnosisofhypochromiasinchildhood AT marinalopesdefreitasfreire hypopigmentedmycosisfungoidesanimportantdifferentialdiagnosisofhypochromiasinchildhood AT tamaratavaresdacruz hypopigmentedmycosisfungoidesanimportantdifferentialdiagnosisofhypochromiasinchildhood AT luizarennorochadeoliveira hypopigmentedmycosisfungoidesanimportantdifferentialdiagnosisofhypochromiasinchildhood |