Single-cell atlas of human skin implicates APOE pro-inflammatory signaling in diabetic foot ulcers

Single-cell atlas of human skin implicates APOE pro-inflammatory signaling in diabetic foot ulcers

BackgroundDiabetic foot ulcers (DFU) are a major global complication of diabetes mellitus, yet their underlying mechanisms remain incompletely understood. Fibroblasts are key regulators in the finely tuned process of wound healing.MethodsSingle-cell RNA sequencing was performed on human skin tissues...

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Bibliographic Details
Main Authors: Yating Yin, Li Li, Mingen Liu, Bin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
single-cell RNA sequencing
diabetic foot ulcers
apolipoprotein E
human skin fibroblasts
inflammatory disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1591944/full
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