ZIF-8 with encapsulated dihydroartemisinin in a drug delivery system for protection against Plasmodium berghei ANKA-induced experimental cerebral malaria in C57BL/6N mice

ZIF-8 with encapsulated dihydroartemisinin in a drug delivery system for protection against Plasmodium berghei ANKA-induced experimental cerebral malaria in C57BL/6N mice

ABSTRACT Cerebral malaria (CM), primarily caused by Plasmodium falciparum, is the primary cause of malaria-related fatalities. CM treatment faces significant challenges due to limited therapeutic options and the emergence of antimalarial drug resistance. Dihydroartemisinin (DHA) is the first-line th...

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Bibliographic Details
Main Authors: Yuting Li, Liu-Gen Li, Huiyin Zhu, Daiqian Zhu, Haimei Shi, Wei Wang, Jinyu Mo, Jianhai Yin, Tong-fei Li, Jian Li
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
cerebral malaria
dihydroartemisinin
nanodrug
drug delivery
zeolitic imidazolate framework-8
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02366-24
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