The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis
Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. The etiology and pathogenetic mechanisms of osteoporosis have not been clearly elucidated. Osteoporosis is linked to bone resorption by the activation of the osteoclastogenic process. The breakdown of...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/434389 |
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| author | Danilo Pagliari Francesco Ciro Tamburrelli Gianfranco Zirio Estelle E. Newton Rossella Cianci |
| author_facet | Danilo Pagliari Francesco Ciro Tamburrelli Gianfranco Zirio Estelle E. Newton Rossella Cianci |
| author_sort | Danilo Pagliari |
| collection | DOAJ |
| description | Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. The etiology and pathogenetic mechanisms of osteoporosis have not been clearly elucidated. Osteoporosis is linked to bone resorption by the activation of the osteoclastogenic process. The breakdown of homeostasis among pro- and antiosteoclastogenic cells causes unbalanced bone remodeling. The complex interactions among these cells in the bone microenvironment involve several mediators and proinflammatory pathways. Thus, we may consider the bone microenvironment as a complex system in which local and systemic immunity are regulated and we propose to consider it as an “immunological niche.” The study of the “bone immunological niche” will permit a better understanding of the complex cell trafficking which regulates bone resorption and disease. The goal of a perfect therapy for osteoporosis would be to potentiate good cells and block the bad ones. In this scenario, additional factors may take part in helping or hindering the proosteoblastogenic factors. Several proosteoblastogenic and antiosteoclastogenic agents have already been identified and some have been developed and commercialized as biological therapies for osteoporosis. Targeting the cellular network of the “bone immunological niche” may represent a successful strategy to better understand and treat osteoporosis and its complications. |
| format | Article |
| id | doaj-art-a4591fcd02334b4bbc4476feffe98982 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-a4591fcd02334b4bbc4476feffe989822025-08-20T03:38:24ZengWileyAnalytical Cellular Pathology2210-71772210-71852015-01-01201510.1155/2015/434389434389The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of OsteoporosisDanilo Pagliari0Francesco Ciro Tamburrelli1Gianfranco Zirio2Estelle E. Newton3Rossella Cianci4Institute of Internal Medicine, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, ItalyInstitute of Orthopedics, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, ItalyInstitute of Orthopedics, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, ItalyCytoCure LLC, 100 Cummings Center, Suite 430C, Beverly, MA 01915, USAInstitute of Internal Medicine, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, ItalyOsteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. The etiology and pathogenetic mechanisms of osteoporosis have not been clearly elucidated. Osteoporosis is linked to bone resorption by the activation of the osteoclastogenic process. The breakdown of homeostasis among pro- and antiosteoclastogenic cells causes unbalanced bone remodeling. The complex interactions among these cells in the bone microenvironment involve several mediators and proinflammatory pathways. Thus, we may consider the bone microenvironment as a complex system in which local and systemic immunity are regulated and we propose to consider it as an “immunological niche.” The study of the “bone immunological niche” will permit a better understanding of the complex cell trafficking which regulates bone resorption and disease. The goal of a perfect therapy for osteoporosis would be to potentiate good cells and block the bad ones. In this scenario, additional factors may take part in helping or hindering the proosteoblastogenic factors. Several proosteoblastogenic and antiosteoclastogenic agents have already been identified and some have been developed and commercialized as biological therapies for osteoporosis. Targeting the cellular network of the “bone immunological niche” may represent a successful strategy to better understand and treat osteoporosis and its complications.http://dx.doi.org/10.1155/2015/434389 |
| spellingShingle | Danilo Pagliari Francesco Ciro Tamburrelli Gianfranco Zirio Estelle E. Newton Rossella Cianci The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis Analytical Cellular Pathology |
| title | The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis |
| title_full | The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis |
| title_fullStr | The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis |
| title_full_unstemmed | The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis |
| title_short | The Role of “Bone Immunological Niche” for a New Pathogenetic Paradigm of Osteoporosis |
| title_sort | role of bone immunological niche for a new pathogenetic paradigm of osteoporosis |
| url | http://dx.doi.org/10.1155/2015/434389 |
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